In this section
@article{Rees:2022:10.1542/peds.2022-057442,
author = {Rees, P and Callan, C and Chadda, K and Vaal, M and Diviney, J and Sabti, S and Harnden, F and Gardiner, J and Battersby, C and Gale, C and Sutcliffe, A},
doi = {10.1542/peds.2022-057442},
journal = {Pediatrics},
pages = {1--15},
title = {Preterm brain injury and neurodevelopmental outcomes: a meta-analysis},
url = {http://dx.doi.org/10.1542/peds.2022-057442},
volume = {150},
year = {2022}
}
TY - JOUR
AB - Context:Preterm brain injuries are common; neurodevelopmental outcomes following contemporary neonatal care are continually evolving.Objective:To systematically review and meta-analyze neurodevelopmental outcomes among preterm infants after intraventricular hemorrhage (IVH) and white matter injury (WMI). Data Sources:Published and grey literature were searched across 10 databases between 2000-2021Study Selection:Observational studies reporting 3-year neurodevelopmental outcomes for preterm infants with IVH or WMI compared to preterm infants without injury.Data extraction:Study characteristics, population characteristics, and outcome data were extracted.Results:38 studies were included. There was an increased adjusted risk of moderate-severe neurodevelopmental impairment after IVH grade 1-2 (aOR 1.35 [95% CI 1.05, 1.75]) and IVH grade 3-4 (aOR 4.26 [3.25, 5.59]). Children with IVH grade 1-2 had higher risks of cerebral palsy (OR 1.76 [1.39, 2.24)], cognitive (OR 1.79 [1.09, 2.95]), hearing (OR 1.83 CI [1.03. 3.24]), and visual impairment (OR 1.77 [1.08, 2.9]). Children with IVH grade 3-4 had markedly higher risks of cerebral palsy (OR 4.98 [4.13, 6.00)], motor (OR 2.7 [1.52, 4.8)], cognitive (OR 2.3 [1.67, 3.15)], hearing (OR 2.44 [1.42, 4.2)), and visual impairment (OR 5.42 [2.77, 10.58)). Children with WMI had much higher risks of cerebral palsy (OR 14.91 [7.3, 30.46), motor (OR 5.3 [3, 9.36)], and cognitive impairment (OR 3.48 [2.18, 5.53)).Limitations:Heterogeneity of outcome data.Conclusions:Mild IVH, severe IVH, and WMI are associated with adverse neurodevelopmental outcomes. Utilization of core outcomes sets and availability of open-access study data would improve our understanding of the nuances of these outcomes.
AU - Rees,P
AU - Callan,C
AU - Chadda,K
AU - Vaal,M
AU - Diviney,J
AU - Sabti,S
AU - Harnden,F
AU - Gardiner,J
AU - Battersby,C
AU - Gale,C
AU - Sutcliffe,A
DO - 10.1542/peds.2022-057442
EP - 15
PY - 2022///
SN - 0031-4005
SP - 1
TI - Preterm brain injury and neurodevelopmental outcomes: a meta-analysis
T2 - Pediatrics
UR - http://dx.doi.org/10.1542/peds.2022-057442
UR - https://publications.aap.org/pediatrics/article/150/6/e2022057442/189905/Preterm-Brain-Injury-and-Neurodevelopmental?autologincheck=redirected
UR - http://hdl.handle.net/10044/1/99795
VL - 150
ER -
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