In this section
@article{Webbe:2022:10.1136/bmjpo-2022-001543,
author = {Webbe, J and Battersby, C and Longford, N and Ougham, K and Uthaya, S and Modi, N and Gale, C},
doi = {10.1136/bmjpo-2022-001543},
journal = {BMJ Paediatrics Open},
title = {Use of parenteral nutrition in the first postnatal week in England and Wales: An observational study using real-world data},
url = {http://dx.doi.org/10.1136/bmjpo-2022-001543},
volume = {6},
year = {2022}
}
TY - JOUR
AB - BackgroundParenteral nutrition (PN) is used to provide supplemental support to neonates while enteral feeding is being established. PN is a high-cost intervention with beneficial and harmful effects. Internationally there is substantial variation in how PN is used, and there are limited contemporary data describing use across the UK. ObjectiveTo describe PN use in the first postnatal week in infants born and admitted to neonatal care in England, Scotland and Wales.MethodData describing neonates admitted to National Health Service (NHS) neonatal units between 1st January 2012 and 31st December 2017, extracted from routinely recorded data held the National Neonatal Research Database (NNRD); the denominator was live births, from Office for National Statistics.ResultsOver the study period 62,145 neonates were given PN in the first postnatal week (1.4% of all live births); use was higher in more preterm neonates (76% of livebirths at <28 weeks, 0.2% of term livebirths) and in neonates with lower birth weight. 15% (9181/62145) of neonates given PN in the first postnatal week were born at term. There was geographic variation in PN administration: the proportion of live births given PN within neonatal regional networks ranged from 1.0% (95% confidence intervals: 1.0, 1.0) to 2.8% (95% confidence interval: 2.7, 2.9). Conclusions and relevanceSignificant variation exists in neonatal PN use; it is unlikely this reflects optimal use of an expensive intervention. Research is needed to identify which babies will benefit most and which are at risk of harm from early PN. RegistrationClinicalTrials.gov: NCT03767634
AU - Webbe,J
AU - Battersby,C
AU - Longford,N
AU - Ougham,K
AU - Uthaya,S
AU - Modi,N
AU - Gale,C
DO - 10.1136/bmjpo-2022-001543
PY - 2022///
SN - 2399-9772
TI - Use of parenteral nutrition in the first postnatal week in England and Wales: An observational study using real-world data
T2 - BMJ Paediatrics Open
UR - http://dx.doi.org/10.1136/bmjpo-2022-001543
UR - http://hdl.handle.net/10044/1/98561
VL - 6
ER -
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