BibTex format
@article{Greenbury:2021:10.1016/S2352-4642(21)00232-7,
author = {Greenbury, SF and Angelini, ED and Ougham, K and Battersby, C and Gale, C and Uthaya, S and Modi, N},
doi = {10.1016/S2352-4642(21)00232-7},
journal = {The Lancet Child & Adolescent Health},
pages = {719--728},
title = {Birthweight and patterns of postnatal weight gain in very and extremely preterm babies in England and Wales, 2008-19: a cohort study},
url = {http://dx.doi.org/10.1016/S2352-4642(21)00232-7},
volume = {5},
year = {2021}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND: Intrauterine and postnatal weight are widely regarded as biomarkers of fetal and neonatal wellbeing, but optimal weight gain following preterm birth is unknown. We aimed to describe changes over time in birthweight and postnatal weight gain in very and extremely preterm babies, in relation to major morbidity and healthy survival. METHODS: In this cohort study, we used whole-population data from the UK National Neonatal Research Database for infants below 32 weeks gestation admitted to neonatal units in England and Wales between Jan 1, 2008, and Dec 31, 2019. We used non-linear Gaussian process to estimate monthly trends, and Bayesian multilevel regression to estimate unadjusted and adjusted coefficients. We evaluated birthweight; weight change from birth to 14 days; weight at 36 weeks postmenstrual age; associated Z scores; and longitudinal weights for babies surviving to 36 weeks postmenstrual age with and without major morbidities. We adjusted birthweight for antenatal, perinatal, and demographic variables. We additionally adjusted change in weight at 14 days and weight at 36 weeks postmenstrual age, and their Z scores, for postnatal variables. FINDINGS: The cohort comprised 90 817 infants. Over the 12-year period, mean differences adjusted for antenatal, perinatal, demographic, and postnatal variables were 0 g (95% compatibility interval -7 to 7) for birthweight (-0·01 [-0·05 to 0·03] for change in associated Z score); 39 g (26 to 51) for change in weight from birth to 14 days (0·14 [0·08 to 0·19] for change in associated Z score); and 105 g (81 to 128) for weight at 36 weeks postmenstrual age (0·27 [0·21 to 0·33] for change in associated Z score). Greater weight at 36 weeks postmenstrual age was robust to additional adjustment for enteral nutritional intake. In babies surviving without major morbidity, weight velocity in all gestational age groups stabilised at around 34 weeks post
AU - Greenbury,SF
AU - Angelini,ED
AU - Ougham,K
AU - Battersby,C
AU - Gale,C
AU - Uthaya,S
AU - Modi,N
DO - 10.1016/S2352-4642(21)00232-7
EP - 728
PY - 2021///
SN - 2352-4642
SP - 719
TI - Birthweight and patterns of postnatal weight gain in very and extremely preterm babies in England and Wales, 2008-19: a cohort study
T2 - The Lancet Child & Adolescent Health
UR - http://dx.doi.org/10.1016/S2352-4642(21)00232-7
UR - https://www.ncbi.nlm.nih.gov/pubmed/34450109
UR - https://www.sciencedirect.com/science/article/pii/S2352464221002327?via%3Dihub
UR - http://hdl.handle.net/10044/1/91418
VL - 5
ER -
