In this section
@article{Britzman:2018:10.1038/s41598-018-23405-3,
author = {Britzman, D and Igah, I and Eftaxiopoulou, T and Macdonald, W and Bull, AMJ},
doi = {10.1038/s41598-018-23405-3},
journal = {Scientific Reports},
title = {Tibial osteotomy as a mechanical model of primary osteoarthritis in rats},
url = {http://dx.doi.org/10.1038/s41598-018-23405-3},
volume = {8},
year = {2018}
}
TY - JOUR
AB - This study has presented the rst purely biomechanical surgical model of osteoarthritis (OA) in rats, which could be more representative of the human primary disease than intra-articular techniques published previously. A surgical tibial osteotomy (TO) was used to induce degenerative cartilage changes in the medial knee of Sprague-Dawley rats. The presence of osteoarthritic changes in the medial knee compartment of the operated animals was evaluated histologically and through analysis of serum carboxy-terminal telepeptides of type II collagen (CTX-II). In-vivo biomechanical analyses were carried out using a musculoskeletal model of the rat hindlimb to evaluate the loading conditions in the knee pre and post-surgically. Qualitative and quantitative medial cartilage degeneration consistent with OA was found in the knees of the operated animals alongside elevated CTX-II levels and increased tibial compressive loading. The potential avoidance of joint inammation post-surgically, the maintenance of internal joint biomechanics and the ability to quantify the alterations in joint loading should make this model of OA a better candidate for modeling primary forms of the disease in humans.
AU - Britzman,D
AU - Igah,I
AU - Eftaxiopoulou,T
AU - Macdonald,W
AU - Bull,AMJ
DO - 10.1038/s41598-018-23405-3
PY - 2018///
SN - 2045-2322
TI - Tibial osteotomy as a mechanical model of primary osteoarthritis in rats
T2 - Scientific Reports
UR - http://dx.doi.org/10.1038/s41598-018-23405-3
UR - http://hdl.handle.net/10044/1/57540
VL - 8
ER -
Professor Anthony Bull
Department of Bioengineering
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Imperial College London
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