BibTex format
@article{Evans:2021:10.1016/S2213-2600(21)00383-0,
author = {Evans, RA and McAuley, H and Harrison, EM and Shikotra, A and Singapuri, A and Sereno, M and Elneima, O and Docherty, AB and Lone, NI and Leavy, OC and Daines, L and Baillie, JK and Brown, JS and Chalder, T and De, Soyza A and Diar, Bakerly N and Easom, N and Geddes, JR and Greening, NJ and Hart, N and Heaney, LG and Heller, S and Howard, L and Hurst, JR and Jacob, J and Jenkins, RG and Jolley, C and Kerr, S and Kon, OM and Lewis, K and Lord, JM and McCann, GP and Neubauer, S and Openshaw, PJM and Parekh, D and Pfeffer, P and Rahman, NM and Raman, B and Richardson, M and Rowland, M and Semple, MG and Shah, AM and Singh, SJ and Sheikh, A and Thomas, D and Toshner, M and Chalmers, JD and Ho, L-P and Horsley, A and Marks, M and Poinasamy, K and Wain, LV and Brightling, CE and PHOSP-COVID, Collaborative Group},
doi = {10.1016/S2213-2600(21)00383-0},
journal = {The Lancet Respiratory Medicine},
pages = {1275--1287},
title = {Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study},
url = {http://dx.doi.org/10.1016/S2213-2600(21)00383-0},
volume = {9},
year = {2021}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND: The impact of COVID-19 on physical and mental health and employment after hospitalisation with acute disease is not well understood. The aim of this study was to determine the effects of COVID-19-related hospitalisation on health and employment, to identify factors associated with recovery, and to describe recovery phenotypes. METHODS: The Post-hospitalisation COVID-19 study (PHOSP-COVID) is a multicentre, long-term follow-up study of adults (aged ≥18 years) discharged from hospital in the UK with a clinical diagnosis of COVID-19, involving an assessment between 2 and 7 months after discharge, including detailed recording of symptoms, and physiological and biochemical testing. Multivariable logistic regression was done for the primary outcome of patient-perceived recovery, with age, sex, ethnicity, body-mass index, comorbidities, and severity of acute illness as covariates. A post-hoc cluster analysis of outcomes for breathlessness, fatigue, mental health, cognitive impairment, and physical performance was done using the clustering large applications k-medoids approach. The study is registered on the ISRCTN Registry (ISRCTN10980107). FINDINGS: We report findings for 1077 patients discharged from hospital between March 5 and Nov 30, 2020, who underwent assessment at a median of 5·9 months (IQR 4·9-6·5) after discharge. Participants had a mean age of 58 years (SD 13); 384 (36%) were female, 710 (69%) were of white ethnicity, 288 (27%) had received mechanical ventilation, and 540 (50%) had at least two comorbidities. At follow-up, only 239 (29%) of 830 participants felt fully recovered, 158 (20%) of 806 had a new disability (assessed by the Washington Group Short Set on Functioning), and 124 (19%) of 641 experienced a health-related change in occupation. Factors associated with not recovering were female sex, middle age (40-59 years), two or more comorbidities, and more severe acute illness. The magnitude of the persistent health bur
AU - Evans,RA
AU - McAuley,H
AU - Harrison,EM
AU - Shikotra,A
AU - Singapuri,A
AU - Sereno,M
AU - Elneima,O
AU - Docherty,AB
AU - Lone,NI
AU - Leavy,OC
AU - Daines,L
AU - Baillie,JK
AU - Brown,JS
AU - Chalder,T
AU - De,Soyza A
AU - Diar,Bakerly N
AU - Easom,N
AU - Geddes,JR
AU - Greening,NJ
AU - Hart,N
AU - Heaney,LG
AU - Heller,S
AU - Howard,L
AU - Hurst,JR
AU - Jacob,J
AU - Jenkins,RG
AU - Jolley,C
AU - Kerr,S
AU - Kon,OM
AU - Lewis,K
AU - Lord,JM
AU - McCann,GP
AU - Neubauer,S
AU - Openshaw,PJM
AU - Parekh,D
AU - Pfeffer,P
AU - Rahman,NM
AU - Raman,B
AU - Richardson,M
AU - Rowland,M
AU - Semple,MG
AU - Shah,AM
AU - Singh,SJ
AU - Sheikh,A
AU - Thomas,D
AU - Toshner,M
AU - Chalmers,JD
AU - Ho,L-P
AU - Horsley,A
AU - Marks,M
AU - Poinasamy,K
AU - Wain,LV
AU - Brightling,CE
AU - PHOSP-COVID,Collaborative Group
DO - 10.1016/S2213-2600(21)00383-0
EP - 1287
PY - 2021///
SN - 2213-2600
SP - 1275
TI - Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study
T2 - The Lancet Respiratory Medicine
UR - http://dx.doi.org/10.1016/S2213-2600(21)00383-0
UR - https://www.ncbi.nlm.nih.gov/pubmed/34627560
UR - https://www.sciencedirect.com/science/article/pii/S2213260021003830?via%3Dihub
UR - http://hdl.handle.net/10044/1/92216
VL - 9
ER -