BibTex format
@article{Grech-Sollars:2015:10.1002/nbm.3269,
author = {Grech-Sollars, M and Hales, PW and Miyazaki, K and Raschke, F and Rodriguez, D and Wilson, M and Gill, SK and Banks, T and Saunders, DE and Clayden, JD and Gwilliam, MN and Barrick, TR and Morgan, PS and Davies, NP and Rossiter, J and Auer, DP and Grundy, R and Leach, MO and Howe, FA and Peet, AC and Clark, CA},
doi = {10.1002/nbm.3269},
journal = {NMR in Biomedicine},
pages = {468--485},
title = {Multi-centre reproducibility of diffusion MRI parameters for clinical sequences in the brain.},
url = {http://dx.doi.org/10.1002/nbm.3269},
volume = {28},
year = {2015}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - The purpose of this work was to assess the reproducibility of diffusion imaging, and in particular the apparent diffusion coefficient (ADC), intra-voxel incoherent motion (IVIM) parameters and diffusion tensor imaging (DTI) parameters, across multiple centres using clinically available protocols with limited harmonization between sequences. An ice-water phantom and nine healthy volunteers were scanned across fives centres on eight scanners (four Siemens 1.5T, four Philips 3T). The mean ADC, IVIM parameters (diffusion coefficient D and perfusion fraction f) and DTI parameters (mean diffusivity MD and fractional anisotropy FA), were measured in grey matter, white matter and specific brain sub-regions. A mixed effect model was used to measure the intra- and inter-scanner coefficient of variation (CV) for each of the five parameters. ADC, D, MD and FA had a good intra- and inter-scanner reproducibility in both grey and white matter, with a CV ranging between 1% and 7.4%; mean 2.6%. Other brain regions also showed high levels of reproducibility except for small structures such as the choroid plexus. The IVIM parameter f had a higher intra-scanner CV of 8.4% and inter-scanner CV of 24.8%. No major difference in the inter-scanner CV for ADC, D, MD and FA was observed when analysing the 1.5T and 3T scanners separately. ADC, D, MD and FA all showed good intra-scanner reproducibility, with the inter-scanner reproducibility being comparable or faring slightly worse, suggesting that using data from multiple scanners does not have an adverse effect compared with using data from the same scanner. The IVIM parameter f had a poorer inter-scanner CV when scanners of different field strengths were combined, and the parameter was also affected by the scan acquisition resolution. This study shows that the majority of diffusion MRI derived parameters are robust across 1.5T and 3T scanners and suitable for use in multi-centre clinical studies and trials.
AU - Grech-Sollars,M
AU - Hales,PW
AU - Miyazaki,K
AU - Raschke,F
AU - Rodriguez,D
AU - Wilson,M
AU - Gill,SK
AU - Banks,T
AU - Saunders,DE
AU - Clayden,JD
AU - Gwilliam,MN
AU - Barrick,TR
AU - Morgan,PS
AU - Davies,NP
AU - Rossiter,J
AU - Auer,DP
AU - Grundy,R
AU - Leach,MO
AU - Howe,FA
AU - Peet,AC
AU - Clark,CA
DO - 10.1002/nbm.3269
EP - 485
PY - 2015///
SN - 0952-3480
SP - 468
TI - Multi-centre reproducibility of diffusion MRI parameters for clinical sequences in the brain.
T2 - NMR in Biomedicine
UR - http://dx.doi.org/10.1002/nbm.3269
UR - http://hdl.handle.net/10044/1/23847
VL - 28
ER -