BibTex format
@article{Grant:2024:cid/ciae558,
author = {Grant, R and de, Kraker MEA and Buetti, N and Jackson, H and Abbas, M and Sobel, JA and Sommerstein, R and Eder, M and Balmelli, C and Troillet, N and Schreiber, PW and Jent, P and Senn, L and Flury, D and Tschudin-Sutter, S and Buettcher, M and Süveges, M and Urbini, L and Keiser, O and Roder, U and Harbarth, S and Zanella, M-C and CH-SUR, study group},
doi = {cid/ciae558},
journal = {Clin Infect Dis},
title = {In-hospital outcomes of healthcare-associated COVID-19 (Omicron) versus healthcare-associated influenza: a retrospective, nationwide cohort study in Switzerland.},
url = {http://dx.doi.org/10.1093/cid/ciae558},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND: As COVID-19 is integrated into existing infectious disease control programs, it is important to understand the comparative clinical impact of COVID-19 and other respiratory diseases. METHODS: We conducted a retrospective cohort study of patients with symptomatic healthcare-associated COVID-19 or influenza reported to the nationwide, hospital-based surveillance system in Switzerland. Included patients were adults (≥18 years) hospitalized for ≥3 days in tertiary care and large regional hospitals. Patients had COVID-19 symptoms and a RT-PCR-confirmed SARS-CoV-2 infection ≥3 days after hospital admission between 1 February 2022 and 30 April 2023, or influenza symptoms and a RT-PCR-confirmed influenza A or B infection ≥3 days after hospital admission between 1 November 2018 and 30 April 2023. Primary and secondary outcomes were 30-day in-hospital mortality and admission to intensive care unit (ICU), respectively. Cox regression (Fine-Gray model) was used to account for time-dependency and competing events, with inverse probability weighting to adjust for confounding. RESULTS: We included 2901 patients with symptomatic healthcare-associated COVID-19 (Omicron) and 868 patients with symptomatic healthcare-associated influenza from nine hospitals. We found a similar case fatality ratio between healthcare-associated COVID-19 (Omicron) (6.2%) and healthcare-associated influenza (6.1%) patients; after adjustment, patients had a comparable subdistribution hazard ratio for 30-day in-hospital mortality (0.91, 95%CI 0.67-1.24). A similar proportion of patients were admitted to ICU (2.4% COVID-19; 2.6% influenza). CONCLUSIONS: COVID-19 and influenza continue to cause severe disease among hospitalized patients. Our results suggest that in-hospital mortality risk of healthcare-associated COVID-19 (Omicron) and healthcare-associated influenza are comparable.
AU - Grant,R
AU - de,Kraker MEA
AU - Buetti,N
AU - Jackson,H
AU - Abbas,M
AU - Sobel,JA
AU - Sommerstein,R
AU - Eder,M
AU - Balmelli,C
AU - Troillet,N
AU - Schreiber,PW
AU - Jent,P
AU - Senn,L
AU - Flury,D
AU - Tschudin-Sutter,S
AU - Buettcher,M
AU - Süveges,M
AU - Urbini,L
AU - Keiser,O
AU - Roder,U
AU - Harbarth,S
AU - Zanella,M-C
AU - CH-SUR,study group
DO - cid/ciae558
PY - 2024///
TI - In-hospital outcomes of healthcare-associated COVID-19 (Omicron) versus healthcare-associated influenza: a retrospective, nationwide cohort study in Switzerland.
T2 - Clin Infect Dis
UR - http://dx.doi.org/10.1093/cid/ciae558
UR - https://www.ncbi.nlm.nih.gov/pubmed/39535247
ER -