In this section
@article{Ghani:2024,
author = {Ghani, R and Chrysostomou, D and Roberts, LA and Pandiaraja, M and Marchesi, JR and Mullish, BH},
journal = {Gut Microbes},
title = {Faecal (or intestinal) microbiota transplant: a tool for repairing the gut microbiome},
url = {http://hdl.handle.net/10044/1/115399},
year = {2024}
}
TY - JOUR
AB - Faecal/ intestinal microbiota transplant (FMT/ IMT) is an efficacious treatment option for recurrent Clostridioides difficile infection, which has prompted substantial interest in FMT’s potential role in the management of a much broader range of diseases associated with the gut microbiome. Despite its promise, the success rates of FMT have been variable. This review critically evaluates the current evidence on the effect of clinical, biological and procedural factors on the therapeutic efficacy of FMT, and identifies areas that remain nebulous. Due to some of these factors, the optimal therapeutic approach remains unclear; for example, the timing of FMT administration in a heavily antibiotic-exposed haematopoietic cell transplant recipient is not standardised, with arguments that can be made in alternate directions. We explore how these factors may impact upon more informed selection of donors, potential matching of donors to recipients, and aspects of clinical care of FMT recipients. This includes consideration of how gut microbiome composition and functionality may strategically inform donor selection criteria. Furthermore, we review how the most productive advances within the FMT space are those where clinical and translational outcomes are assessed together, and where this model has been used productively in recent years to better understand the contribution of the gut microbiome to human disease, and start the process towards development of more targeted microbiome therapeutics.
AU - Ghani,R
AU - Chrysostomou,D
AU - Roberts,LA
AU - Pandiaraja,M
AU - Marchesi,JR
AU - Mullish,BH
PY - 2024///
SN - 1949-0976
TI - Faecal (or intestinal) microbiota transplant: a tool for repairing the gut microbiome
T2 - Gut Microbes
UR - http://hdl.handle.net/10044/1/115399
ER -
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