BibTex format
@article{Molinaro:2020:10.1038/s41467-020-19589-w,
author = {Molinaro, A and Bel, Lassen P and Henricsson, M and Wu, H and Adriouch, S and Belda, E and Chakaroun, R and Nielsen, T and Bergh, P-O and Rouault, C and Andre, S and Marquet, F and Andreelli, F and Salem, J-E and Assmann, K and Bastard, J-P and Forslund, S and Le, Chatelier E and Falony, G and Pons, N and Prifti, E and Quinquis, B and Roume, H and Vieira-Silva, S and Hansen, TH and Pedersen, HK and Lewinter, C and Sonderskov, NB and Kober, L and Vestergaard, H and Hansen, T and Zucker, J-D and Galan, P and Dumas, M-E and Raes, J and Oppert, J-M and Letunic, I and Nielsen, J and Bork, P and Ehrlich, SD and Stumvoll, M and Pedersen, O and Aron-Wisneswky, J and Clement, K and Backhed, F},
doi = {10.1038/s41467-020-19589-w},
journal = {Nature Communications},
title = {Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology},
url = {http://dx.doi.org/10.1038/s41467-020-19589-w},
volume = {11},
year = {2020}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.
AU - Molinaro,A
AU - Bel,Lassen P
AU - Henricsson,M
AU - Wu,H
AU - Adriouch,S
AU - Belda,E
AU - Chakaroun,R
AU - Nielsen,T
AU - Bergh,P-O
AU - Rouault,C
AU - Andre,S
AU - Marquet,F
AU - Andreelli,F
AU - Salem,J-E
AU - Assmann,K
AU - Bastard,J-P
AU - Forslund,S
AU - Le,Chatelier E
AU - Falony,G
AU - Pons,N
AU - Prifti,E
AU - Quinquis,B
AU - Roume,H
AU - Vieira-Silva,S
AU - Hansen,TH
AU - Pedersen,HK
AU - Lewinter,C
AU - Sonderskov,NB
AU - Kober,L
AU - Vestergaard,H
AU - Hansen,T
AU - Zucker,J-D
AU - Galan,P
AU - Dumas,M-E
AU - Raes,J
AU - Oppert,J-M
AU - Letunic,I
AU - Nielsen,J
AU - Bork,P
AU - Ehrlich,SD
AU - Stumvoll,M
AU - Pedersen,O
AU - Aron-Wisneswky,J
AU - Clement,K
AU - Backhed,F
DO - 10.1038/s41467-020-19589-w
PY - 2020///
SN - 2041-1723
TI - Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/s41467-020-19589-w
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000595687000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://www.nature.com/articles/s41467-020-19589-w
UR - http://hdl.handle.net/10044/1/99122
VL - 11
ER -