BibTex format
@article{Brial:2020:10.1016/j.celrep.2020.01.066,
author = {Brial, F and Alzaid, F and Sonomura, K and Kamatani, Y and Meneyrol, K and Le, Lay A and Pean, N and Hedjazi, L and Sato, T-A and Venteclef, N and Magnan, C and Lathrop, M and Dumas, M-E and Matsuda, F and Zalloua, P and Gauguier, D},
doi = {10.1016/j.celrep.2020.01.066},
journal = {Cell Reports},
pages = {2306--2320},
title = {The natural metabolite 4-cresol improves glucose homeostasis and enhances beta-cell function},
url = {http://dx.doi.org/10.1016/j.celrep.2020.01.066},
volume = {30},
year = {2020}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Exposure to natural metabolites contributes to the risk of cardiometabolic diseases (CMDs). Through metabolome profiling, we identify the inverse correlation between serum concentrations of 4-cresol and type 2 diabetes. The chronic administration of non-toxic doses of 4-cresol in complementary preclinical models of CMD reduces adiposity, glucose intolerance, and liver triglycerides, enhances insulin secretion in vivo, stimulates islet density and size, and pancreatic β-cell proliferation, and increases vascularization, suggesting activated islet enlargement. In vivo insulin sensitivity is not affected by 4-cresol. The incubation of mouse isolated islets with 4-cresol results in enhanced insulin secretion, insulin content, and β-cell proliferation of a magnitude similar to that induced by GLP-1. In both CMD models and isolated islets, 4-cresol is associated with the downregulated expression of the kinase DYRK1A, which may mediate its biological effects. Our findings identify 4-cresol as an effective regulator of β-cell function, which opens up perspectives for therapeutic applications in syndromes of insulin deficiency.
AU - Brial,F
AU - Alzaid,F
AU - Sonomura,K
AU - Kamatani,Y
AU - Meneyrol,K
AU - Le,Lay A
AU - Pean,N
AU - Hedjazi,L
AU - Sato,T-A
AU - Venteclef,N
AU - Magnan,C
AU - Lathrop,M
AU - Dumas,M-E
AU - Matsuda,F
AU - Zalloua,P
AU - Gauguier,D
DO - 10.1016/j.celrep.2020.01.066
EP - 2320
PY - 2020///
SN - 2211-1247
SP - 2306
TI - The natural metabolite 4-cresol improves glucose homeostasis and enhances beta-cell function
T2 - Cell Reports
UR - http://dx.doi.org/10.1016/j.celrep.2020.01.066
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000514824500022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://www.sciencedirect.com/science/article/pii/S2211124720300917?via%3Dihub
UR - http://hdl.handle.net/10044/1/79053
VL - 30
ER -