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@article{Barriga:2015:10.1039/c4sm02343a,
author = {Barriga, HMG and Tyler, AII and McCarthy, NLC and Parsons, ES and Ces, O and Law, RV and Seddon, JM and Brooks, NJ},
doi = {10.1039/c4sm02343a},
journal = {Soft Matter},
pages = {600--607},
title = {Temperature and pressure tuneable swollen bicontinuous cubic phases approaching nature's length scales},
url = {http://dx.doi.org/10.1039/c4sm02343a},
volume = {11},
year = {2015}
}
TY - JOUR
AB - Bicontinuous cubic structures offer enormous potential in applications ranging from protein crystallisation to drug delivery systems and have been observed in cellular membrane structures. One of the current bottlenecks in understanding and exploiting these structures is that cubic scaffolds produced in vitro are considerably smaller in size than those observed in biological systems, differing by almost an order of magnitude in some cases. We have addressed this technological bottleneck and developed a methodology capable of manufacturing highly swollen bicontinuous cubic membranes with length scales approaching those seen in vivo. Crucially, these cubic systems do not require the presence of proteins. We have generated highly swollen Im3m symmetry bicontinuous cubic phases with lattice parameters of up to 480 Å, composed of ternary mixtures of monoolein, cholesterol and negatively charged lipid (DOPS or DOPG) and we have been able to tune their lattice parameters. The swollen cubic phases are highly sensitive to both temperature and pressure; these structural changes are likely to be controlled by a fine balance between lipid headgroup repulsions and lateral pressure in the hydrocarbon chain region.
AU - Barriga,HMG
AU - Tyler,AII
AU - McCarthy,NLC
AU - Parsons,ES
AU - Ces,O
AU - Law,RV
AU - Seddon,JM
AU - Brooks,NJ
DO - 10.1039/c4sm02343a
EP - 607
PY - 2015///
SN - 1744-683X
SP - 600
TI - Temperature and pressure tuneable swollen bicontinuous cubic phases approaching nature's length scales
T2 - Soft Matter
UR - http://dx.doi.org/10.1039/c4sm02343a
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346911600018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/19425
VL - 11
ER -
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