Theme 3: Endothelial Resilience

From pathophysiology to a translational treatment target in CVD 

Endothelial resilience refers to the remarkable ability of endothelial cells, which line the interior surface of blood vessels, to maintain functionality and adapt to various physiological challenges and stressors. These resilient cells play a pivotal role in regulating vascular tone, permeability, and inflammatory responses, thereby influencing overall cardiovascular health. Through intricate mechanisms endothelial cells exhibit resilience against factors such as oxidative stress, inflammation, and other noxious influences that harm the cardiovascular system. Our theme will aim to explore restoring as well as enhancing endothelial resilience, which is increasingly recognised as a key therapeutic target in preventing and managing cardiovascular diseases. Our work underscores the importance of maintaining endothelial health as a vital part of maintaining overall cardiovascular homeostasis and longevity.

Theme leads

Co-applicants

Christopher Rhodes

Christopher Rhodes

Costanza Emanueli

Costanza Emanueli

Declan O’Regan

Declan O’Regan

Ed Tate

Ed Tate

Jesus Gil

Jesus Gil

Julia Gorelik

Julia Gorelik

Manuel Mayr

Manuel Mayr

Michela Noseda

Michela Noseda

Key investigators

Alastair Webb

Alastair Webb

Asha Patel

Asha Patel

Beata Wojciak-Stothard

Beata Wojciak-Stothard

Cesare Terracciano

Cesare Terracciano

Graeme Birdsey

Graeme Birdsey

Jane Mitchell

Jane Mitchell

Joseph Boyle

Joseph Boyle

Koralia Paschalaki

Koralia Paschalaki

Prashant Srivastava

Prashant Srivastava

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Faculty of MedicineNational Heart and Lung InstituteVascular Science Network