BibTex format
@article{Nooredinvand:2015:10.3748/wjg.v21.i29.8920,
author = {Nooredinvand, HA and Connell, DW and Asgheddi, M and Abdullah, M and O'Donoghue, M and Campbell, L and Wickremasinghe, MI and Lalvani, A and Kon, OM and Khan, SA},
doi = {10.3748/wjg.v21.i29.8920},
journal = {World Journal of Gastroenterology},
pages = {8920--8926},
title = {Viral hepatitis prevalence in patients with active and latent tuberculosis},
url = {http://dx.doi.org/10.3748/wjg.v21.i29.8920},
volume = {21},
year = {2015}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - AIM: To assess the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and association with drug induced liver injury (DILI) in patients undergoing anti-tuberculosis (TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB - either active disease or latent infection - who were due to commence anti-TB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus (HIV) infections - hepatitis B core antigen (HBcAg), hepatitis B surface antigen (HBsAg), hepatitis B e antigen, IgG and IgM antibody to HBcAg (anti-HBc), HCV IgG antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of anti-TB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher’s exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270 (62.9%) had active TB disease and 159 (37.1%) had latent TB infection. 61 (14.2%) patients had isolated anti-HBc positivity, 11 (2.6%) were also HBsAg positive and 7 (1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis (HBsAg or HCV antibody positive; P = 0.023). Similarly the proportion of HBsAg positive patients were significantly greater in the active vs latent TB infection group (10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each
AU - Nooredinvand,HA
AU - Connell,DW
AU - Asgheddi,M
AU - Abdullah,M
AU - O'Donoghue,M
AU - Campbell,L
AU - Wickremasinghe,MI
AU - Lalvani,A
AU - Kon,OM
AU - Khan,SA
DO - 10.3748/wjg.v21.i29.8920
EP - 8926
PY - 2015///
SN - 1007-9327
SP - 8920
TI - Viral hepatitis prevalence in patients with active and latent tuberculosis
T2 - World Journal of Gastroenterology
UR - http://dx.doi.org/10.3748/wjg.v21.i29.8920
UR - http://hdl.handle.net/10044/1/41832
VL - 21
ER -
