BibTex format
@article{Halliday:2021:10.3310/eme08050,
author = {Halliday, A and Jain, P and Hoang, L and Parker, R and Tolosa-Wright, M and Masonou, T and Green, N and Boakye, A and Takwoingi, Y and Hamilton, S and Mandagere, V and Fries, A and Coin, L and Deeks, J and White, PJ and Levin, M and Beverley, P and Kon, OM and Lalvani, A},
doi = {10.3310/eme08050},
journal = {Efficacy and Mechanism Evaluation},
pages = {1--160},
title = {New technologies for diagnosing active TB: the VANTDET diagnostic accuracy study},
url = {http://dx.doi.org/10.3310/eme08050},
volume = {8},
year = {2021}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - <jats:sec id="abs1-1"> <jats:title>Background</jats:title> <jats:p>Tuberculosis (TB) is a devastating disease for which new diagnostic tests are desperately needed.</jats:p> </jats:sec> <jats:sec id="abs1-2"> <jats:title>Objective</jats:title> <jats:p>To validate promising new technologies [namely whole-blood transcriptomics, proteomics, flow cytometry and quantitative reverse transcription-polymerase chain reaction (qRT-PCR)] and existing signatures for the detection of active TB in samples obtained from individuals with suspected active TB.</jats:p> </jats:sec> <jats:sec id="abs1-3"> <jats:title>Design</jats:title> <jats:p>Four substudies, each of which used samples from the biobank collected as part of the interferon gamma release assay (IGRA) in the Diagnostic Evaluation of Active TB study, which was a prospective cohort of patients recruited with suspected TB.</jats:p> </jats:sec> <jats:sec id="abs1-4"> <jats:title>Setting</jats:title> <jats:p>Secondary care.</jats:p> </jats:sec> <jats:sec id="abs1-5"> <jats:title>Participants</jats:title> <jats:p>Adults aged ≥ 16 years presenting as inpatients or outpatients at 12 NHS hospital trusts in London, Slough, Oxford, Leicester and Birmingham, with suspected active TB.</jats:p> </jats:sec> <jats:sec id="abs1-6"> <jats:title>Interventions</jats:title> <jats:p>New tests using genome-wide gene expression microarray
AU - Halliday,A
AU - Jain,P
AU - Hoang,L
AU - Parker,R
AU - Tolosa-Wright,M
AU - Masonou,T
AU - Green,N
AU - Boakye,A
AU - Takwoingi,Y
AU - Hamilton,S
AU - Mandagere,V
AU - Fries,A
AU - Coin,L
AU - Deeks,J
AU - White,PJ
AU - Levin,M
AU - Beverley,P
AU - Kon,OM
AU - Lalvani,A
DO - 10.3310/eme08050
EP - 160
PY - 2021///
SN - 2050-4365
SP - 1
TI - New technologies for diagnosing active TB: the VANTDET diagnostic accuracy study
T2 - Efficacy and Mechanism Evaluation
UR - http://dx.doi.org/10.3310/eme08050
VL - 8
ER -
