BibTex format
@article{Cordery:2022:10.1016/S2666-5247(21)00332-3,
author = {Cordery, R and Purba, A and Begum, L and Mills, E and Mosavie, M and Vieira, A and Jauneikaite, E and Leung, RCY and Siggins, M and Ready, D and Hoffman, P and Lamagni, T and Sriskandan, S},
doi = {10.1016/S2666-5247(21)00332-3},
journal = {The Lancet Microbe},
pages = {e366--e375},
title = {Frequency of transmission, asymptomatic shedding, and airborne spread of Streptococcus pyogenes in schoolchildren exposed to scarlet fever: a prospective, longitudinal, multicohort, molecular epidemiological, contact-tracing study in England, UK},
url = {http://dx.doi.org/10.1016/S2666-5247(21)00332-3},
volume = {3},
year = {2022}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundDespite recommendations regarding prompt treatment of cases and enhanced hygiene measures, scarlet fever outbreaks increased in England between 2014 and 2018. We aimed to assess the effects of standard interventions on transmission of Streptococcus pyogenes to classroom contacts, households, and classroom environments to inform future guidance.MethodsWe did a prospective, longitudinal, multicohort, molecular epidemiological, contact-tracing study in six settings across five schools in Greater London, UK. Schools and nurseries were eligible to participate if they had reported two cases of scarlet fever within 10 days of each other among children aged 2–8 years from the same class, with the most recent case arising in the preceding 48 h. We cultured throat swabs from children with scarlet fever, classroom contacts, and household contacts at four timepoints. We also cultured hand swabs and cough plates from all cases in years 1 and 2 of the study, and from classroom contacts in year 2. Surface swabs from toys and other fomites in classrooms were cultured in year 1, and settle plates from classrooms were collected in year 2. Any sample with S pyogenes detected was recorded as positive and underwent emm genotyping and genome sequencing to compare with the outbreak strain.FindingsSix classes, comprising 12 cases of scarlet fever, 17 household contacts, and 278 classroom contacts were recruited between March 1 and May 31, 2018 (year 1), and between March 1 and May 31, 2019 (year 2). Asymptomatic throat carriage of the outbreak strains increased from 11 (10%) of 115 swabbed children in week 1, to 34 (27%) of 126 in week 2, to 26 (24%) of 108 in week 3, and then five (14%) of 35 in week 4. Compared with carriage of outbreak S pyogenes strains, colonisation with non-outbreak and non-genotyped S pyogenes strains occurred in two (2%) of 115 swabbed children in week 1, five (4%) of 126 in week 2, six (6%) of 108 in week 3, and in none of the 35 children in week 4
AU - Cordery,R
AU - Purba,A
AU - Begum,L
AU - Mills,E
AU - Mosavie,M
AU - Vieira,A
AU - Jauneikaite,E
AU - Leung,RCY
AU - Siggins,M
AU - Ready,D
AU - Hoffman,P
AU - Lamagni,T
AU - Sriskandan,S
DO - 10.1016/S2666-5247(21)00332-3
EP - 375
PY - 2022///
SN - 2666-5247
SP - 366
TI - Frequency of transmission, asymptomatic shedding, and airborne spread of Streptococcus pyogenes in schoolchildren exposed to scarlet fever: a prospective, longitudinal, multicohort, molecular epidemiological, contact-tracing study in England, UK
T2 - The Lancet Microbe
UR - http://dx.doi.org/10.1016/S2666-5247(21)00332-3
UR - https://www.medrxiv.org/content/10.1101/2021.07.04.21259990v1
UR - https://www.sciencedirect.com/science/article/pii/S2666524721003323
UR - http://hdl.handle.net/10044/1/92856
VL - 3
ER -
