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@article{Collin:2019:10.1016/j.jinf.2019.11.008,
author = {Collin, SM and Lamb, P and Jauneikaite, E and Le, Doare K and Creti, R and Berardi, A and Heath, PT and Sriskandan, S and Lamagni, T},
doi = {10.1016/j.jinf.2019.11.008},
journal = {Journal of Infection},
pages = {521--527},
title = {Hospital clusters of invasive Group B Streptococcal disease: a systematic review},
url = {http://dx.doi.org/10.1016/j.jinf.2019.11.008},
volume = {79},
year = {2019}
}
TY - JOUR
AB - Objectives: To characterize outbreaks of invasive Group B Streptococcal (iGBS) disease in hospitals.Methods: Systematic review using electronic databases to identify studies describing iGBS outbreaks/clusters or cross-infection/acquisition in healthcare settings where ‘cluster’ was defined as ≥2 linked cases. PROSPERO CRD42018096297.Results: Twenty-five references were included describing 30 hospital clusters (26 neonatal, 4 adult) in 11 countries from 1966 to 2019. Cross-infection between unrelated neonates was reported in 19 clusters involving an early-onset (<7 days of life; n=3), late-onset (7–90 days; n=13) index case or colonized infant (n=3) followed by one or more late-onset cases (median serial interval 9 days (IQR 3–17, range 0–50 days, n=45)); linkage was determined by phage typing in 3 clusters, PFGE/MLST/PCR in 8, WGS in 4, non-molecular methods in 4. Postulated routes of transmission in neonatal clusters were via clinical personnel and equipment, particularly during periods of crowding and high patient-to-nurse ratio. Of 4 adult clusters, one was attributed to droplet spread between respiratory cases, one to handling of haemodialysis catheters and two unspecified.Conclusions: Long intervals between cases were identified in most of the clusters, a characteristic which potentially hinders detection of GBS hospital outbreaks without enhanced surveillance supported by genomics.
AU - Collin,SM
AU - Lamb,P
AU - Jauneikaite,E
AU - Le,Doare K
AU - Creti,R
AU - Berardi,A
AU - Heath,PT
AU - Sriskandan,S
AU - Lamagni,T
DO - 10.1016/j.jinf.2019.11.008
EP - 527
PY - 2019///
SN - 0163-4453
SP - 521
TI - Hospital clusters of invasive Group B Streptococcal disease: a systematic review
T2 - Journal of Infection
UR - http://dx.doi.org/10.1016/j.jinf.2019.11.008
UR - http://hdl.handle.net/10044/1/75227
VL - 79
ER -
