Below is an outline of early clinical and preclinical research activities focussed on therapeutics in the field of haematology, involving avademics from the Centre for Haematology.
Haemato-Oncology
- Multiple Myeloma: First in man clinical development of GADDβ45 inhibitor.
- Pre-clinical development of GCN2 and PBX1 inhibitors
- HTLV-1 adult T cell lymphoma: Clinical development of anti-CCR4 Ab for treatment of pre-malignant ATL
- Clinical and pre-clinical development of iNKT cell-based immunotherapy
- Stem cell transplantation and cellular immunotherapy (point of care CAR-T immunotherapy).
Red cell haematology and Immunohaematology
- Haemoglobinopathies and Thalassaemias: Gene therapy including gene editing
- Hereditary haemolytic anaemias: Novel allosteric glycolytic enzyme modulators
- Immune thrombocytopenia: Novel immunomodulating small molecules.
Thrombosis and Haemostasis
- Discovery and pre-clinical developments of raft of mAbs as novel anti-coagulations