BibTex format
@article{Brady:2017:10.1016/S2214-109X(17)30220-6,
author = {Brady, OJ and Slater, HC and Pemberton-Ross, P and Wenger, E and Maude, RJ and Ghani, AC and Penny, MA and Gerardin, J and White, LJ and Chitnis, N and Aguas, R and Hay, SI and Smith, DL and Stuckey, EM and Okiro, EA and Smith, TA and Okell, LC},
doi = {10.1016/S2214-109X(17)30220-6},
journal = {The Lancet Global Health},
pages = {E680--E687},
title = {Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study},
url = {http://dx.doi.org/10.1016/S2214-109X(17)30220-6},
volume = {5},
year = {2017}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundMass drug administration for elimination of Plasmodium falciparum malaria is recommended by WHO in some settings. We used consensus modelling to understand how to optimise the effects of mass drug administration in areas with low malaria transmission.MethodsWe collaborated with researchers doing field trials to establish a standard intervention scenario and standard transmission setting, and we input these parameters into four previously published models. We then varied the number of rounds of mass drug administration, coverage, duration, timing, importation of infection, and pre-administration transmission levels. The outcome of interest was the percentage reduction in annual mean prevalence of P falciparum parasite rate as measured by PCR in the third year after the final round of mass drug administration.FindingsThe models predicted differing magnitude of the effects of mass drug administration, but consensus answers were reached for several factors. Mass drug administration was predicted to reduce transmission over a longer timescale than accounted for by the prophylactic effect alone. Percentage reduction in transmission was predicted to be higher and last longer at lower baseline transmission levels. Reduction in transmission resulting from mass drug administration was predicted to be temporary, and in the absence of scale-up of other interventions, such as vector control, transmission would return to pre-administration levels. The proportion of the population treated in a year was a key determinant of simulated effectiveness, irrespective of whether people are treated through high coverage in a single round or new individuals are reached by implementation of several rounds. Mass drug administration was predicted to be more effective if continued over 2 years rather than 1 year, and if done at the time of year when transmission is lowest.InterpretationMass drug administration has the potential to reduce transmission for a limited time, but is not an
AU - Brady,OJ
AU - Slater,HC
AU - Pemberton-Ross,P
AU - Wenger,E
AU - Maude,RJ
AU - Ghani,AC
AU - Penny,MA
AU - Gerardin,J
AU - White,LJ
AU - Chitnis,N
AU - Aguas,R
AU - Hay,SI
AU - Smith,DL
AU - Stuckey,EM
AU - Okiro,EA
AU - Smith,TA
AU - Okell,LC
DO - 10.1016/S2214-109X(17)30220-6
EP - 687
PY - 2017///
SN - 2214-109X
SP - 680
TI - Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study
T2 - The Lancet Global Health
UR - http://dx.doi.org/10.1016/S2214-109X(17)30220-6
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000403063600024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/50670
VL - 5
ER -