In this section
@article{Walker:2013:10.1038/ncomms2605,
author = {Walker, PGT and Griffin, JT and Cairns, M and Rogerson, SJ and van, Eijk AM and ter, Kuile F and Ghani, AC},
doi = {10.1038/ncomms2605},
journal = {Nature Communications},
title = {A model of parity-dependent immunity to placental malaria},
url = {http://dx.doi.org/10.1038/ncomms2605},
volume = {4},
year = {2013}
}
TY - JOUR
AB - Plasmodium falciparum placental infection during pregnancy is harmful for both mother andchild. Protection from placental infection is parity-dependent, that is, acquired over consecutivepregnancies. However, the infection status of the placenta can only be assessed atdelivery. Here, to better understand the mechanism underlying this parity-dependence, wefitted a model linking malaria dynamics within the general population to observed placentalhistology. Our results suggest that immunity resulting in less prolonged infection is a greaterdeterminant of the parity-specific patterns than immunity that prevents placental sequestration.Our results also suggest the time when maternal blood first flows into the placenta isa high-risk period. Therefore, preventative strategies implementable before or early inpregnancy, such as insecticide-treated net usage in women of child-bearing age or any futurevaccine, could substantially reduce the number of women who experience placental infection.
AU - Walker,PGT
AU - Griffin,JT
AU - Cairns,M
AU - Rogerson,SJ
AU - van,Eijk AM
AU - ter,Kuile F
AU - Ghani,AC
DO - 10.1038/ncomms2605
PY - 2013///
SN - 2041-1723
TI - A model of parity-dependent immunity to placental malaria
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/ncomms2605
UR - http://hdl.handle.net/10044/1/28688
VL - 4
ER -