BibTex format
@article{Verity:2020:10.1038/s41467-020-15779-8,
author = {Verity, R and Aydemir, O and Brazeau, NF and Watson, OJ and Hathaway, NJ and Mwandagalirwa, MK and Marsh, PW and Thwai, K and Fulton, T and Denton, M and Morgan, AP and Parr, JB and Tumwebaze, PK and Conrad, M and Rosenthal, PJ and Ishengoma, DS and Ngondi, J and Gutman, J and Mulenga, M and Norris, DE and Moss, WJ and Mensah, BA and Myers-Hansen, JL and Ghansah, A and Tshefu, AK and Ghani, AC and Meshnick, SR and Bailey, JA and Juliano, JJ},
doi = {10.1038/s41467-020-15779-8},
journal = {Nature Communications},
pages = {1--10},
title = {The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC.},
url = {http://dx.doi.org/10.1038/s41467-020-15779-8},
volume = {11},
year = {2020}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationally representative population sample from DRC and samples from surrounding countries, using molecular inversion probes - a high-throughput genotyping tool. We identify an east-west divide in haplotypes known to confer resistance to chloroquine and sulfadoxine-pyrimethamine. Furthermore, we identify highly related parasites over large geographic distances, indicative of gene flow and migration. Our results are consistent with a background of isolation by distance combined with the effects of selection for antimalarial drug resistance. This study provides a high-resolution view of parasite genetic structure across a large country in Africa and provides a baseline to study how implementation programs may impact parasite populations.
AU - Verity,R
AU - Aydemir,O
AU - Brazeau,NF
AU - Watson,OJ
AU - Hathaway,NJ
AU - Mwandagalirwa,MK
AU - Marsh,PW
AU - Thwai,K
AU - Fulton,T
AU - Denton,M
AU - Morgan,AP
AU - Parr,JB
AU - Tumwebaze,PK
AU - Conrad,M
AU - Rosenthal,PJ
AU - Ishengoma,DS
AU - Ngondi,J
AU - Gutman,J
AU - Mulenga,M
AU - Norris,DE
AU - Moss,WJ
AU - Mensah,BA
AU - Myers-Hansen,JL
AU - Ghansah,A
AU - Tshefu,AK
AU - Ghani,AC
AU - Meshnick,SR
AU - Bailey,JA
AU - Juliano,JJ
DO - 10.1038/s41467-020-15779-8
EP - 10
PY - 2020///
SN - 2041-1723
SP - 1
TI - The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC.
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/s41467-020-15779-8
UR - https://www.ncbi.nlm.nih.gov/pubmed/32355199
UR - https://www.nature.com/articles/s41467-020-15779-8
UR - http://hdl.handle.net/10044/1/79378
VL - 11
ER -