In this section
@article{Yue:2024:10.1039/d4cc05223d,
author = {Yue, TTC and Teh, JH and Aboagye, E and Ma, MT and Pham, TT and Long, NJ},
doi = {10.1039/d4cc05223d},
journal = {Chem Commun (Camb)},
title = {Site-specific π-clamp-mediated radiosynthesis of 68Ga and 18F PET radiopharmaceuticals.},
url = {http://dx.doi.org/10.1039/d4cc05223d},
year = {2024}
}
TY - JOUR
AB - The π-clamp-mediated conjugation method, which enables site-specific modification of cysteine residues, is a promising strategy for developing well-defined radiolabelled biomolecules for positron emission tomography (PET) imaging. We have applied this method to site-specifically attach the macrocyclic chelators "NODA" and "NODAGA" to the somatostatin receptor 2-targeted peptide, octreotate. The resulting novel NODA-octreotate and NODAGA-octreotate compounds can be radiolabelled with either [18F]AlF- or [68Ga]Ga3+ respectively. In vivo PET imaging shows that the [68Ga]Ga3+-labelled derivative exhibits high stability and favourable pharmacokinetic properties.
AU - Yue,TTC
AU - Teh,JH
AU - Aboagye,E
AU - Ma,MT
AU - Pham,TT
AU - Long,NJ
DO - 10.1039/d4cc05223d
PY - 2024///
TI - Site-specific π-clamp-mediated radiosynthesis of 68Ga and 18F PET radiopharmaceuticals.
T2 - Chem Commun (Camb)
UR - http://dx.doi.org/10.1039/d4cc05223d
UR - https://www.ncbi.nlm.nih.gov/pubmed/39661407
ER -
Professor Nick Long
Email: n.long@imperial.ac.uk
Telephone: +44 (0)20 7594 5781
501J
Molecular Sciences Research Hub
White City Campus
