In this section
@article{Peeva:2016:10.1002/anie.201607795,
author = {Peeva, LG and Da, Silva Burgal J and Heckenast, Z and Brazy, F and Cazenave, F and Livingston, A},
doi = {10.1002/anie.201607795},
journal = {Angewandte Chemie International Edition},
pages = {13576--13579},
title = {Continuous consecutive reactions with inter-reaction solvent exchange by membrane separation},
url = {http://dx.doi.org/10.1002/anie.201607795},
volume = {55},
year = {2016}
}
TY - JOUR
AB - Pharmaceutical production typically involves multiple reaction steps with separations between successive reactions. Two processes which complicate the transition from batch to continuous operation in multistep synthesis are solvent exchange (especially highboiling to lowboilingpoint solvent), and catalyst separation. Demonstrated here is membrane separation as an enabling platform for undertaking these processes during continuous operation. Two consecutive reactions are performed in different solvents, with catalyst separation and interreaction solvent exchange achieved by continuous flow membrane units. A Heck coupling reaction is performed in N,Ndimethylformamide (DMF) in a continuous membrane reactor which retains the catalyst. The Heck reaction product undergoes solvent exchange in a countercurrent membrane system where DMF is continuously replaced by ethanol. After exchange the product dissolved in ethanol passes through a column packed with an iron catalyst, and undergoes reduction (>99 % yield).
AU - Peeva,LG
AU - Da,Silva Burgal J
AU - Heckenast,Z
AU - Brazy,F
AU - Cazenave,F
AU - Livingston,A
DO - 10.1002/anie.201607795
EP - 13579
PY - 2016///
SN - 1433-7851
SP - 13576
TI - Continuous consecutive reactions with inter-reaction solvent exchange by membrane separation
T2 - Angewandte Chemie International Edition
UR - http://dx.doi.org/10.1002/anie.201607795
UR - https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201607795
UR - http://hdl.handle.net/10044/1/40047
VL - 55
ER -