The research theme Integrative Systems Biology brings together the members of the Department who are developing and applying mathematical, statistical and computational approaches to understand biology. The research grouping includes both theoretician and experimentalist who pursue this interdisciplinary approach. Studies span numerous scales ranging from the molecular through the cellular to ecosystems and biodiversity.
Members of the theme are modelling metabolic networks, cellular development and sleep patterns across a wide range of prokaryotic and eukaryotic organisms. Recent research has identified environmental drivers of SAR-CoV-2 lineage and has applied structure-based modelling to identify that a common TMPRSS2 missense variant presents a protective effect against severe Covid-19. The theme is committed to developing and disseminating bioinformatics and systems modelling resources to the community via web servers and downloadable code including software for predicting protein structure and genetic variants.
Institutes, centres and initiatives
This Research Theme is associated to the following institutes, centres and initiatives:
- Artificial Intelligence Network
- Centre for Integrative Systems Biology and Bioinformatics
- European Bioinformatics Institute
- The Francis Crick Institute
- The Imperial College Centre for Synthetic Biology
- Physics of Life Network
- Wound Healing and Regeneration Network
Academic staff in this area
Professor Stephen G Brickley
Professor Stephen G Brickley
Professor of Systems Neuroscience
Professor Martin Buck FRS
Professor Martin Buck FRS
Senior Research Investigator
Dr Laurence Bugeon
Dr Laurence Bugeon
Research Fellow
Dr Tiago Cunha Luis
Dr Tiago Cunha Luis
Sir Henry Dale Fellow
Professor Maggie Dallman OBE
Professor Maggie Dallman OBE
Associate Provost (Societal Engagement)
Professor Robert G Endres
Professor Robert G Endres
Professor of Systems Biology
Professor Nick Franks FMedSci FRS
Professor Nick Franks FMedSci FRS
Professor of Biophysics and Anaesthetics
Dr Matteo Fumagalli
Dr Matteo Fumagalli
Visiting Researcher
Dr Giorgio F Gilestro
Dr Giorgio F Gilestro
Reader in Systems Neurobiology
Dr Richard J Gill
Dr Richard J Gill
Reader in Evolutionary & Experimental Ecology
Dr Derek M Huntley
Dr Derek M Huntley
Senior Teaching Fellow
Professor Mark Isalan
Professor Mark Isalan
Professor of Synthetic Biology
Dr Jose Jimenez Zarco
Dr Jose Jimenez Zarco
Reader in Synthetic Biology
Professor Patrik R Jones
Professor Patrik R Jones
Visiting Professor
Professor Cristina Lo Celso
Professor Cristina Lo Celso
Co-Director Centre for Haematology & Prof Stem Cell Biology
Dr Julie A K McDonald PhD
Dr Julie A K McDonald PhD
Senior Lecturer
Dr James W Murray
Dr James W Murray
Reader in Structural Biology of Photosynthesis
Dr Masahiro Ono
Dr Masahiro Ono
Reader in Immunology
Professor Samraat Pawar
Professor Samraat Pawar
Professor of Theoretical Ecology
Dr Will Pearse
Dr Will Pearse
Reader in Evolutionary Ecology
Dr Ruben Perez-Carrasco
Dr Ruben Perez-Carrasco
Senior Lecturer in Theoretical Systems Biology
Dr Giovanni Sena
Dr Giovanni Sena
Senior Lecturer
Professor Michael J E Sternberg
Professor Michael J E Sternberg
Director, Systems Biology and Bioinformatics Centre
Professor Bill Wisden FMedSci FRS
Professor Bill Wisden FMedSci FRS
Chair in Molecular Neuroscience
Professor Guy Woodward
Professor Guy Woodward
Professor of Ecology
Postgraduate research
Interested in studying a PhD at the Department of Life Sciences? Find out more about postgraduate research opportunties.