In this section
@article{Kundu:2024,
author = {Kundu, S and Dos, Santos Correia G and Lee, Y and Ng, S and Sykes, L and Chan, D and Lewis, H and Brown, R and Kindinger, L and Dell, A and Feizi, T and Haslam, S and Liu, Y and Marchesi, J and MacIntyre, D and Bennett, P},
journal = {Microbial Genomics},
title = {Secretor status is a modifier of vaginal microbiota-associated preterm birth risk},
url = {http://hdl.handle.net/10044/1/115305},
year = {2024}
}
TY - JOUR
AB - Mutations in the FUT2 gene that result in a lack of expression of histo-blood group antigens on secreted glycoproteins may shape the vaginal microbiota with consequences for birth outcome. To test this, we analysed the relationship between secretor status, vaginal microbiota and gestational length in an ethnically diverse cohort of 302 pregnant women, including 82 who delivered preterm. Lactobacillus gasseri and Lactobacillus jensenii were found to have distinct co-occurrence patterns with other microbial taxa in non-secretors. Moreover, non-secretors with Lactobacillus spp. depleted, high diversity vaginal microbiota in early pregnancy had significantly shorter gestational length than Lactobacillus spp. dominated non-secretors (mean of 241.54 days (SD=47.14) versus 266.21 (23.61); p-value=0.0251). Similar gestational length was observed between non-secretors with high vaginal diversity and secretors with Lactobacillus spp. dominance (mean of 262.52 days (SD=27.73); p-value=0.0439) or depletion (mean of 266.05 days (SD=20.81); p-value=0.0312). Our data highlight secretor status and blood-group antigen expression as being important mediators of vaginal microbiota-host interactions in the context of preterm birth risk.
AU - Kundu,S
AU - Dos,Santos Correia G
AU - Lee,Y
AU - Ng,S
AU - Sykes,L
AU - Chan,D
AU - Lewis,H
AU - Brown,R
AU - Kindinger,L
AU - Dell,A
AU - Feizi,T
AU - Haslam,S
AU - Liu,Y
AU - Marchesi,J
AU - MacIntyre,D
AU - Bennett,P
PY - 2024///
SN - 2057-5858
TI - Secretor status is a modifier of vaginal microbiota-associated preterm birth risk
T2 - Microbial Genomics
UR - http://hdl.handle.net/10044/1/115305
ER -
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