BibTex format
@article{Graham:2020:10.1016/j.jinf.2020.05.073,
author = {Graham, N and Junghans, C and Downes, R and Sendall, C and Lai, H and McKirdy, A and Elliott, P and Howard, R and Wingfield, D and Priestman, M and Ciechonska, M and Cameron, L and Storch, M and Crone, MA and Freemont, PS and Randell, P and McLaren, R and Lang, N and Ladhani, S and Sanderson, F and Sharp, DJ},
doi = {10.1016/j.jinf.2020.05.073},
journal = {Journal of Infection},
pages = {411--419},
title = {SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes},
url = {http://dx.doi.org/10.1016/j.jinf.2020.05.073},
volume = {81},
year = {2020}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - OBJECTIVES: To understand SARS-Co-V-2 infection and transmission in UK nursing homes in order to develop preventive strategies for protecting the frail elderly residents. METHODS: An outbreak investigation involving 394 residents and 70 staff, was carried out in 4 nursing homes affected by COVID-19 outbreaks in central London. Two point-prevalence surveys were performed one week apart where residents underwent SARS-CoV-2 testing and had relevant symptoms documented. Asymptomatic staff from three of the four homes were also offered SARS-CoV-2 testing. RESULTS: Overall, 26% (95% CI 22 to 31) of residents died over the two-month period. All-cause mortality increased by 203% (95% CI 70 to 336) compared with previous years. Systematic testing identified 40% (95% CI 35 to 46) of residents as positive for SARS-CoV-2, and of these 43% (95% CI 34 to 52) were asymptomatic and 18% (95% CI 11 to 24) had only atypical symptoms; 4% (95% CI -1 to 9) of asymptomatic staff also tested positive. CONCLUSIONS: The SARS-CoV-2 outbreak in four UK nursing homes was associated with very high infection and mortality rates. Many residents developed either atypical or no discernible symptoms. A number of asymptomatic staff members also tested positive, suggesting a role for regular screening of both residents and staff in mitigating future outbreaks.
AU - Graham,N
AU - Junghans,C
AU - Downes,R
AU - Sendall,C
AU - Lai,H
AU - McKirdy,A
AU - Elliott,P
AU - Howard,R
AU - Wingfield,D
AU - Priestman,M
AU - Ciechonska,M
AU - Cameron,L
AU - Storch,M
AU - Crone,MA
AU - Freemont,PS
AU - Randell,P
AU - McLaren,R
AU - Lang,N
AU - Ladhani,S
AU - Sanderson,F
AU - Sharp,DJ
DO - 10.1016/j.jinf.2020.05.073
EP - 419
PY - 2020///
SN - 0163-4453
SP - 411
TI - SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes
T2 - Journal of Infection
UR - http://dx.doi.org/10.1016/j.jinf.2020.05.073
UR - https://www.ncbi.nlm.nih.gov/pubmed/32504743
UR - https://www.sciencedirect.com/science/article/pii/S0163445320303480?via%3Dihub
UR - http://hdl.handle.net/10044/1/79885
VL - 81
ER -