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• Journal article
  Pattani A, McKay PF, Garland MJ, Curran RM, Migalska K, Cassidy CM, Malcolm RK, Shattock RJ, McCarthy HO, Donnelly RFet al., 2012,

  Microneedle mediated intradermal delivery of adjuvanted recombinant HIV-1 CN54gp140 effectively primes mucosal boost inoculations

  , JOURNAL OF CONTROLLED RELEASE, Vol: 162, Pages: 529-537, ISSN: 0168-3659
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  • Citations: 64
• Conference paper
  Mann JF, McKay PF, Swales J, Klein K, Fiserova A, Cope A, Shattock RJet al., 2012,

  Optimising CN54gp140 plasmid delivery by comparing intramuscular and intradermal vaccination combinations with and without electroporation

  , Publisher: BIOMED CENTRAL LTD, ISSN: 1742-4690
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• Conference paper
  McKay PF, Mann JF, Pattani A, Kett VL, Malcolm K, Shattock RJet al., 2012,

  Intravaginal immunization using a novel antigen delivery device elicits robust vaccine antigen-specific systemic and mucosal humoral immune responses

  , Publisher: BIOMED CENTRAL LTD, ISSN: 1742-4690
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  • Citations: 2
• Conference paper
  McKay PF, Cope AV, Swales J, Joseph S, Esteban M, Tatoud R, Carter D, Weber J, Shattock RJet al., 2012,

  Antigen-specific T lymphocyte responses elicited by a DNA - MVA HIV CN54gp140 immunization regime are significantly altered by the TLR4 adjuvant GLA

  , Publisher: BIOMED CENTRAL LTD, ISSN: 1742-4690
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• Journal article
  Du T, Hu K, Yang J, Jin J, Li C, Stieh D, Griffin GE, Shattock RJ, Hu Qet al., 2012,

  Bifunctional CD4-DC-SIGN Fusion Proteins Demonstrate Enhanced Avidity to gp120 and Inhibit HIV-1 Infection and Dissemination

  , ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol: 56, Pages: 4640-4649, ISSN: 0066-4804
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  • Citations: 21
• Journal article
  Stefanidou M, Herrera C, Armanasco N, Shattock RJet al., 2012,

  Saquinavir Inhibits Early Events Associated with Establishment of HIV-1 Infection: Potential Role for Protease Inhibitors in Prevention

  , ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol: 56, Pages: 4381-4390, ISSN: 0066-4804
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  • Citations: 29
• Journal article
  Arias MA, Van Roey GA, Tregoning JS, Moutaftsi M, Coler RN, Windish HP, Reed SG, Carter D, Shattock RJet al., 2012,

  Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 Agonist, Promotes Potent Systemic and Mucosal Responses to Intranasal Immunization with HIVgp140

  , PLOS One, Vol: 7, ISSN: 1932-6203

  Successful vaccine development against HIV will likely require the induction of strong, long-lasting humoral and cellularimmune responses in both the systemic and mucosal compartments. Based on the known immunological linkage betweenthe upper-respiratory and urogenital tracts, we explored the potential of nasal adjuvants to boost immunization for theinduction of vaginal and systemic immune responses to gp140. Mice were immunized intranasally with HIV gp140 togetherwith micellar and emulsion formulations of a synthetic TLR4 agonist, Glucopyranosyl Lipid Adjuvant (GLA) and responseswere compared to R848, a TLR7/8 agonist, or chitosan, a non TLR adjuvant. GLA and chitosan but not R848 greatlyenhanced serum immunoglobulin levels when compared to antigen alone. Both GLA and chitosan induced high IgG andIgA titers in nasal and vaginal lavage and feces. The high IgA and IgG titers in vaginal lavage were associated with highnumbers of gp140-specific antibody secreting cells in the genital tract. Whilst both GLA and chitosan induced T cellresponses to immunization, GLA induced a stronger Th17 response and chitosan induced a more Th2 skewed response. Ourresults show that GLA is a highly potent intranasal adjuvant greatly enhancing humoral and cellular immune responses,both systemically and mucosally.

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• Journal article
  Ruffin N, Borggren M, Euler Z, Fiorino F, Grupping K, Hallengard D, Javed A, Mendonca K, Pollard C, Reinhart D, Saba E, Sheik-Khalil E, Skold A, Ziglio S, Scarlatti G, Gotch F, Wahren B, Shattock RJet al., 2012,

  Rational design of HIV vaccines and microbicides: report of the EUROPRISE annual conference 2011

  , JOURNAL OF TRANSLATIONAL MEDICINE, Vol: 10, ISSN: 1479-5876
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  • Citations: 6
• Journal article
  Huang W, Hu K, Luo S, Zhang M, Li C, Jin W, Liu Y, Griffin GE, Shattock RJ, Hu Qet al., 2012,

  Herpes Simplex Virus Type 2 Infection of Human Epithelial Cells Induces CXCL9 Expression and CD4<SUP>+</SUP> T Cell Migration via Activation of p38-CCAAT/Enhancer-Binding Protein-β Pathway

  , JOURNAL OF IMMUNOLOGY, Vol: 188, Pages: 6247-6257, ISSN: 0022-1767
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  • Citations: 49
• Journal article
  Malcolm RK, Veazey RS, Geer L, Lowry D, Fetherston SM, Murphy DJ, Boyd P, Major I, Shattock RJ, Klasse PJ, Doyle LA, Rasmussen KK, Goldman L, Ketas TJ, Moore JPet al., 2012,

  Sustained Release of the CCR5 Inhibitors CMPD167 and Maraviroc from Vaginal Rings in Rhesus Macaques

  , ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol: 56, Pages: 2251-2258, ISSN: 0066-4804
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  • Citations: 58

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