In this section
@article{Farajzadeh:2021:10.1038/s41598-021-92371-0,
author = {Farajzadeh, Khosroshahi S and Yin, X and Donat, C and McGarry, A and Yanez, Lopez M and Baxan, N and Sharp, D and Sastre, M and Ghajari, M},
doi = {10.1038/s41598-021-92371-0},
journal = {Scientific Reports},
title = {Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses},
url = {http://dx.doi.org/10.1038/s41598-021-92371-0},
volume = {11},
year = {2021}
}
TY - JOUR
AB - Neurovascular injury is often observed in traumatic brain injury (TBI). However, the relationship between mechanical forces and vascular injury is still unclear. A key question is whether the complex anatomy of vasculature plays a role in increasing forces in cerebral vessels and producing damage. We developed a high-fidelity multiscale finite element model of the rat brain featuring a detailed definition of the angioarchitecture. Controlled cortical impacts were performed experimentally and in-silico. The model was able to predict the pattern of blood–brain barrier damage. We found strong correlation between the area of fibrinogen extravasation and the brain area where axial strain in vessels exceeds 0.14. Our results showed that adjacent vessels can sustain profoundly different axial stresses depending on their alignment with the principal direction of stress in parenchyma, with a better alignment leading to larger stresses in vessels. We also found a strong correlation between axial stress in vessels and the shearing component of the stress wave in parenchyma. Our multiscale computational approach explains the unrecognised role of the vascular anatomy and shear stresses in producing distinct distribution of large forces in vasculature. This new understanding can contribute to improving TBI diagnosis and prevention.
AU - Farajzadeh,Khosroshahi S
AU - Yin,X
AU - Donat,C
AU - McGarry,A
AU - Yanez,Lopez M
AU - Baxan,N
AU - Sharp,D
AU - Sastre,M
AU - Ghajari,M
DO - 10.1038/s41598-021-92371-0
PY - 2021///
SN - 2045-2322
TI - Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses
T2 - Scientific Reports
UR - http://dx.doi.org/10.1038/s41598-021-92371-0
UR - http://hdl.handle.net/10044/1/90325
VL - 11
ER -
For queries, please contact Mazdak Ghajari:
If you are interested in the work we do and are interested in postgraduate (PhD) or postdoctoral research, you can find more information about scholarships and fellowships below:
We are also interested in Undergraduate Research Opportunities Programme applicants.
Please get in touch with Mazdak Ghajari in the first instance if interested in applying.
