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@article{Kim:2020:10.1002/adom.201901934,
author = {Kim, JA and Wales, D and Thompson, A and Yang, G-Z},
doi = {10.1002/adom.201901934},
journal = {Advanced Optical Materials},
pages = {1--12},
title = {Fiber-optic SERS probes fabricated using two-photon polymerization for rapid detection of bacteria},
url = {http://dx.doi.org/10.1002/adom.201901934},
volume = {8},
year = {2020}
}
TY - JOUR
AB - This study presents a novel fiber-optic surface-enhanced Raman spectroscopy (SERS) probe (SERS-on-a-tip) fabricated using a simple, two-step protocol based on off-the-shelf components and materials, with a high degree of controllability and repeatability. Two-photon polymerization and subsequent metallization was adopted to fabricate a range of SERS arrays on both planar substrates and end-facets of optical fibers. For the SERS-on-a-tip probes, a limit of detection of 10-7 M (Rhodamine 6G) and analytical enhancement factors of up to 1300 were obtained by optimizing the design, geometry and alignment of the SERS arrays on the tip of the optical fiber. Furthermore, strong repeatability and consistency were achieved for the fabricated SERS arrays, demonstrating that the technique may be suitable for large-scale fabrication procedures in the future. Finally, rapid SERS detection of live Escherichia coli cells was demonstrated using integration times in the milliseconds to seconds range. This result indicates strong potential for in vivo diagnostic use, particularly for detection of infections. Moreover, to the best of our knowledge, this represents the first report of detection of live, unlabeled bacteria using a fiber-optic SERS probe.
AU - Kim,JA
AU - Wales,D
AU - Thompson,A
AU - Yang,G-Z
DO - 10.1002/adom.201901934
EP - 12
PY - 2020///
SN - 2195-1071
SP - 1
TI - Fiber-optic SERS probes fabricated using two-photon polymerization for rapid detection of bacteria
T2 - Advanced Optical Materials
UR - http://dx.doi.org/10.1002/adom.201901934
UR - https://onlinelibrary.wiley.com/doi/full/10.1002/adom.201901934
UR - http://hdl.handle.net/10044/1/75908
VL - 8
ER -
