The 2024 Autumn Term Cardiac Function Seminar series talks will be back Thursday 28th November, to welcome Dr Giancarlo Forte, King’s College London.
Talk Title: Pathological mechanosensing in the human heart
Talk Time: 12:30 – 13:30 UK time
Location: Hybrid Meeting (Hybrid – online Via Teams and Meeting room 427/428 4th Floor ICTEM, Hammersmith Campus, Du Cane Road W12 0NN
Please note the seminar organizers and the Head of Section would like to request that attendees will in the majority of cases be physically present in the seminar room and a participation via Teams shall be the exception.
Talk summary:
Giancarlo Forte is a Senior Lecturer in Cardiac Mechanobiology at British Heart Foundation (BHF) Centre of Excellence at the School of Cardiovascular and Metabolic Medicine and Sciences (SCMMS), King’s College London, United Kingdom. He also holds a Senior Research Team Leader position at the International Clinical Research Centre of St. Anne’s University Hospital in Brno, Czech Republic (FNUSA-ICRC).
Dr. Forte obtained his PhD from the Medical Faculty of the University of Rome Tor Vergata (Italy) in 2005. During his studies, he was a visiting fellow at the University Karls Eberhard in Tübingen, Germany. After his graduation, he became a postdoctoral fellow at the Italian Institute for Cardiovascular Research (INRC), where he was awarded the Young Investigator Award for his research on cell-matrix interaction in 2008.
During his postdoctoral experience, he was a visiting scientist at Tokyo Women’s Medical University (2006), and at National Institute for Materials Science (NIMS, 2010) in Japan. In 2010 he was appointed Senior Researcher at NIMS, in Japan and MANA Scientist at the World Premiere Institute for Materials Nanoarchitectonics (MANA) in the same country, where he worked until 2013.
From 2014 to 2023 he served as Founding Director of the Centre for Translational Medicine (CTM) at FNUSA-ICRC in Brno, Czech Republic. He also contributed to establish the Competence Centre for Mechanobiology in Regenerative Medicine, an Austria-Czech Republic joint initiative and the first research centre of this kind in Czech Republic.
From 2019 to 2021 Dr. Forte served as Deputy Director for Science of FNUSA-ICRC.
Forte lab contributed to expand the knowledge on pathological mechanosensing by identifying the positive loop by which Yes Associated Protein (YAP) reinforces focal adhesion assembly in breast cancer cells (Nardone et al., Nat Commun 2017) and by disclosing the molecular basis of mechanosensitive splicing in the failing heart (Martino et al., Sci Transl Med 2022). Additionally, they unveiled the role of YAP mechanosensor in perpetuating adverse ventricular ECM remodelling in the failing human heart (Perestrelo et al., Circ Res
Short bio:
Giancarlo Forte is a Senior Lecturer in Cardiac Mechanobiology at British Heart Foundation (BHF) Centre of Excellence at the School of Cardiovascular and Metabolic Medicine and Sciences (SCMMS), King’s College London, United Kingdom. He also holds a Senior Research Team Leader position at the International Clinical Research Centre of St. Anne’s University Hospital in Brno, Czech Republic (FNUSA-ICRC).
Dr. Forte obtained his PhD from the Medical Faculty of the University of Rome Tor Vergata (Italy) in 2005. During his studies, he was a visiting fellow at the University Karls Eberhard in Tübingen, Germany. After his graduation, he became a postdoctoral fellow at the Italian Institute for Cardiovascular Research (INRC), where he was awarded the Young Investigator Award for his research on cell-matrix interaction in 2008.
During his postdoctoral experience, he was a visiting scientist at Tokyo Women’s Medical University (2006), and at National Institute for Materials Science (NIMS, 2010) in Japan. In 2010 he was appointed Senior Researcher at NIMS, in Japan and MANA Scientist at the World Premiere Institute for Materials Nanoarchitectonics (MANA) in the same country, where he worked until 2013.
From 2014 to 2023 he served as Founding Director of the Centre for Translational Medicine (CTM) at FNUSA-ICRC in Brno, Czech Republic. He also contributed to establish the Competence Centre for Mechanobiology in Regenerative Medicine, an Austria-Czech Republic joint initiative and the first research centre of this kind in Czech Republic.
From 2019 to 2021 Dr. Forte served as Deputy Director for Science of FNUSA-ICRC.
Forte lab contributed to expand the knowledge on pathological mechanosensing by identifying the positive loop by which Yes Associated Protein (YAP) reinforces focal adhesion assembly in breast cancer cells (Nardone et al., Nat Commun 2017) and by disclosing the molecular basis of mechanosensitive splicing in the failing heart (Martino et al., Sci Transl Med 2022). Additionally, they unveiled the role of YAP mechanosensor in perpetuating adverse ventricular ECM remodelling in the failing human heart (Perestrelo et al., Circ Res
If you are joining online and you have not yet signed up to join the Cardiac Function Seminar Team group in order to participate in the seminar online please register via the linked tab or here which will provide access to the Team.
Please do this ahead of time of the talk.
The Cardiac Function Seminar Team
(Prof. Thomas Brand, Natasha Richmond)
