@article{Govey-Scotland:2023:10.1039/D3LC00691C,
author = {Govey-Scotland, J and Johnstone, L and Myant, C and Friddin, M},
doi = {10.1039/D3LC00691C},
journal = {Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering},
pages = {5068--5080},
title = {Towards a skin-on-a-chip for screening the dermal absorption of cosmetics},
url = {http://dx.doi.org/10.1039/D3LC00691C},
volume = {23},
year = {2023}
}

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TY  - JOUR
AB  - Over the past few decades, there have been increasing global efforts to limit or ban the use of animals for testing cosmetic products. This ambition has been at the heart of international endeavours to develop new in vitro and animal-free approaches for assessing the safety of cosmetics. While several of these new approach methodologies (NAMs) have been approved for assessing different toxicological endpoints in the UK and across the EU, there remains an absence of animal-free methods for screening for dermal absorption; a measure that assesses the degree to which chemical substances can become systemically available through contact with human skin. Here, we identify some of the major technical barriers that have impacted regulatory recognition of an in vitro skin model for this purpose and propose how these could be overcome on-chip using artificial cells engineered from the bottom-up. As part of our future perspective, we suggest how this could be realised using a digital biomanufacturing pipeline that connects the design, microfluidic generation and 3D printing of artificial cells into user-crafted synthetic tissues. We highlight milestone achievements towards this goal, identify future challenges, and suggest how the ability to engineer animal-free skin models could have significant long-term consequences for dermal absorption screening, as well as for other applications.
AU  - Govey-Scotland,J
AU  - Johnstone,L
AU  - Myant,C
AU  - Friddin,M
DO  - 10.1039/D3LC00691C
EP  - 5080
PY  - 2023///
SN  - 1473-0189
SP  - 5068
TI  - Towards a skin-on-a-chip for screening the dermal absorption of cosmetics
T2  - Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering
UR  - http://dx.doi.org/10.1039/D3LC00691C
UR  - https://pubs.rsc.org/en/content/articlelanding/2023/LC/D3LC00691C
UR  - http://hdl.handle.net/10044/1/107476
VL  - 23
ER  - 

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