Molecular Physiology in Critical Care

What we do

Supported by the Wellcome Trust, Medical Research Council, Biotechnology and Biological Sciences Research Council and other charity/industry grants, Professor Takata has established an internationally recognised unique translational research programme in the field of respiratory and critical care medicine at Imperial College. His research group (Critical Care Research Group) consists of a number of postdocs, research assistants and students, including both basic scientists and clinicians. The group investigates the molecular and inflammatory mechanisms of acute lung injury, ventilator-induced lung injury and sepsis-associated organ injury, using in vivo mouse models as the main paradigm with complementary in vitro cell biology, ex vivo isolated organ preparations and clinical studies.

Summary of current research

Specific interests include the tumour necrosis factor signalling, novel roles of monocytes and their subsets, and the development of new anti-inflammatory therapies in these disease models. Over the years the group has developed a wide range of active collaborations across the College and its affiliated NHS Trusts as well as other institutions within UK. Recent focus of the group is placed particularly on clinical translational studies investigating the innate immune system functions in perioperative, critical care, trauma and burns patients.