In this section
@article{Geranmayeh:2017:brain/awx134,
author = {Geranmayeh, F and Wing, Chau T and Wise, RJS and Leech, R and Hampshire, A},
doi = {brain/awx134},
journal = {Brain},
pages = {1947--1958},
title = {Domain-general subregions of the medial prefrontal cortex contribute to recovery of language after stroke},
url = {http://dx.doi.org/10.1093/brain/awx134},
volume = {140},
year = {2017}
}
TY - JOUR
AB - We hypothesized that the recovery of speech production after left hemisphere stroke not only depends on the integrity of language-specialized brain systems, but also on ‘domain-general’ brain systems that have much broader functional roles. The presupplementary motor area/dorsal anterior cingulate forms part of the cingular-opercular network, which has a broad role in cognition and learning. Consequently, we have previously suggested that variability in the recovery of speech production after aphasic stroke may relate in part to differences in patients’ abilities to engage this domain-general brain region. To test our hypothesis, 27 patients (aged 59 ± 11 years) with a left hemisphere stroke performed behavioural assessments and event-related functional magnetic resonance imaging tasks at two time points; first in the early phase (∼2 weeks) and then ∼4 months after the ictus. The functional magnetic resonance imaging tasks were designed to differentiate between activation related to language production (sentential overt speech production—Speech task) and activation related to cognitive processing (non-verbal decision making). Simple rest and counting conditions were also included in the design. Task-evoked regional brain activations during the early and late phases were compared with a longitudinal measure of recovery of language production. In accordance with a role in cognitive processing, substantial activity was observed within the presupplementary motor area/dorsal anterior cingulate during the decision-making task. Critically, the level of activation within this region during speech production correlated positively with the longitudinal recovery of speech production across the two time points (as measured by the in-scanner performance in the Speech task). This relationship was observed for activation in both the early phase (r = 0.363, P = 0.03 one-tailed) and the late phase (r = 0.538, P = 0.004). Furthermore, presupplem
AU - Geranmayeh,F
AU - Wing,Chau T
AU - Wise,RJS
AU - Leech,R
AU - Hampshire,A
DO - brain/awx134
EP - 1958
PY - 2017///
SN - 1460-2156
SP - 1947
TI - Domain-general subregions of the medial prefrontal cortex contribute to recovery of language after stroke
T2 - Brain
UR - http://dx.doi.org/10.1093/brain/awx134
UR - http://hdl.handle.net/10044/1/48167
VL - 140
ER -
