BibTex format
@article{Sam:2015:10.1210/jc.2014-3450,
author = {Sam, AH and Sleeth, ML and Thomas, EL and Ismail, NA and Daud, NM and Chambers, E and Shojaee-Moradie, F and Umpleby, M and Goldstone, AP and Le, Roux CW and Bech, P and Busbridge, M and Laurie, R and Cuthbertson, DJ and Buckley, A and Ghatei, MA and Bloom, SR and Frost, GS and Bell, JD and Murphy, KG},
doi = {10.1210/jc.2014-3450},
journal = {Journal of Clinical Endocrinology and Metabolism},
pages = {1048--1052},
title = {Circulating pancreatic polypeptide concentrations predict visceral and liver fat content},
url = {http://dx.doi.org/10.1210/jc.2014-3450},
volume = {100},
year = {2015}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Context and objective:No current biomarker can reliably predict visceral and liver fat content, both of which are risk factors for cardiovascular disease. Vagal tone has been suggested to influence regional fat deposition. Pancreatic polypeptide (PP) is secreted from the endocrine pancreas under vagal control. We investigated the utility of PP in predicting visceral and liver fat.Patients and Methods:Fasting plasma PP concentrations were measured in 104 overweight and obese subjects (46 men and 58 women). In the same subjects, total and regional adipose tissue, including total visceral adipose tissue (VAT) and total subcutaneous adipose tissue (TSAT), were measured using whole-body magnetic resonance imaging. Intrahepatocellular lipid content (IHCL) was quantified by proton magnetic resonance spectroscopy.Results:Fasting plasma PP concentrations positively and significantly correlated with both VAT (r = 0.57, P < .001) and IHCL (r = 0.51, P < .001), but not with TSAT (r = 0.02, P = .88). Fasting PP concentrations independently predicted VAT after controlling for age and sex. Fasting PP concentrations independently predicted IHCL after controlling for age, sex, body mass index (BMI), waist-to-hip ratio, homeostatic model assessment 2-insulin resistance, (HOMA2-IR) and serum concentrations of triglyceride (TG), total cholesterol (TC), and alanine aminotransferase (ALT). Fasting PP concentrations were associated with serum ALT, TG, TC, low- and high-density lipoprotein cholesterol, and blood pressure (P < .05). These associations were mediated by IHCL and/or VAT. Fasting PP and HOMA2-IR were independently significantly associated with hepatic steatosis (P < .01).Conclusions:Pancreatic polypeptide is a novel predictor of visceral and liver fat content, and thus a potential biomarker for cardiovascular risk stratification and targeted treatment of patients with ectopic fat deposition.
AU - Sam,AH
AU - Sleeth,ML
AU - Thomas,EL
AU - Ismail,NA
AU - Daud,NM
AU - Chambers,E
AU - Shojaee-Moradie,F
AU - Umpleby,M
AU - Goldstone,AP
AU - Le,Roux CW
AU - Bech,P
AU - Busbridge,M
AU - Laurie,R
AU - Cuthbertson,DJ
AU - Buckley,A
AU - Ghatei,MA
AU - Bloom,SR
AU - Frost,GS
AU - Bell,JD
AU - Murphy,KG
DO - 10.1210/jc.2014-3450
EP - 1052
PY - 2015///
SN - 0021-972X
SP - 1048
TI - Circulating pancreatic polypeptide concentrations predict visceral and liver fat content
T2 - Journal of Clinical Endocrinology and Metabolism
UR - http://dx.doi.org/10.1210/jc.2014-3450
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000353358900054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://academic.oup.com/jcem/article/100/3/1048/2839692
UR - http://hdl.handle.net/10044/1/20016
VL - 100
ER -
