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Journal articleBraga RM, Sharp DJ, Leeson C, et al., 2013,
Echoes of the Brain within Default Mode, Association, and Heteromodal Cortices
, JOURNAL OF NEUROSCIENCE, Vol: 33, Pages: 14031-14039, ISSN: 0270-6474- Author Web Link
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- Citations: 86
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Journal articleBraga RM, Wilson LR, Sharp DJ, et al., 2013,
Separable networks for top-down attention to auditory non-spatial and visuospatial modalities
, NEUROIMAGE, Vol: 74, Pages: 77-86, ISSN: 1053-8119- Author Web Link
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- Citations: 47
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Journal articleBonnefond A, Raimondo A, Stutzmann F, et al., 2013,
Loss-of-function mutations in <i>SIM1</i> contribute to obesity and Prader-Willi-like features
, JOURNAL OF CLINICAL INVESTIGATION, Vol: 123, Pages: 3037-3041, ISSN: 0021-9738- Author Web Link
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- Citations: 78
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Journal articleDeal CL, Tony M, Hoybye C, et al., 2013,
Growth Hormone Research Society Workshop Summary: Consensus Guidelines for Recombinant Human Growth Hormone Therapy in Prader-Willi Syndrome
, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 98, Pages: E1072-E1087, ISSN: 0021-972X- Author Web Link
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- Citations: 223
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Journal articlePandit AS, Expert P, Lambiotte R, et al., 2013,
Traumatic brain injury impairs small-world topology
, NEUROLOGY, Vol: 80, Pages: 1826-1833, ISSN: 0028-3878Objective: We test the hypothesis that brain networks associated with cognitive function shift away from a “small-world” organization following traumatic brain injury (TBI).Methods: We investigated 20 TBI patients and 21 age-matched controls. Resting-state functional MRI was used to study functional connectivity. Graph theoretical analysis was then applied to partial correlation matrices derived from these data. The presence of white matter damage was quantified using diffusion tensor imaging.Results: Patients showed characteristic cognitive impairments as well as evidence of damage to white matter tracts. Compared to controls, the graph analysis showed reduced overall connectivity, longer average path lengths, and reduced network efficiency. A particular impact of TBI is seen on a major network hub, the posterior cingulate cortex. Taken together, these results confirm that a network critical to cognitive function shows a shift away from small-world characteristics.Conclusions: We provide evidence that key brain networks involved in supporting cognitive function become less small-world in their organization after TBI. This is likely to be the result of diffuse white matter damage, and may be an important factor in producing cognitive impairment after TBI.
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Journal articleCegla J, Jones B, Seyani L, et al., 2013,
Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism
, CLINICAL ENDOCRINOLOGY, Vol: 78, Pages: 738-742, ISSN: 0300-0664- Author Web Link
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- Citations: 14
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Journal articleHam T, Leff A, de Boissezon X, et al., 2013,
Cognitive Control and the Salience Network: An Investigation of Error Processing and Effective Connectivity
, JOURNAL OF NEUROSCIENCE, Vol: 33, Pages: 7091-+, ISSN: 0270-6474- Author Web Link
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- Citations: 190
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Journal articleSchweizer S, Grahn J, Hampshire A, et al., 2013,
Training the emotional brain: improving affective control through emotional working memory training.
, J Neurosci, Vol: 33, Pages: 5301-5311Affective cognitive control capacity (e.g., the ability to regulate emotions or manipulate emotional material in the service of task goals) is associated with professional and interpersonal success. Impoverished affective control, by contrast, characterizes many neuropsychiatric disorders. Insights from neuroscience indicate that affective cognitive control relies on the same frontoparietal neural circuitry as working memory (WM) tasks, which suggests that systematic WM training, performed in an emotional context, has the potential to augment affective control. Here we show, using behavioral and fMRI measures, that 20 d of training on a novel emotional WM protocol successfully enhanced the efficiency of this frontoparietal demand network. Critically, compared with placebo training, emotional WM training also accrued transfer benefits to a "gold standard" measure of affective cognitive control-emotion regulation. These emotion regulation gains were associated with greater activity in the targeted frontoparietal demand network along with other brain regions implicated in affective control, notably the subgenual anterior cingulate cortex. The results have important implications for the utility of WM training in clinical, prevention, and occupational settings.
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Journal articleHam TE, de Boissezon X, Leff A, et al., 2013,
Distinct Frontal Networks Are Involved in Adapting to Internally and Externally Signaled Errors
, CEREBRAL CORTEX, Vol: 23, Pages: 703-713, ISSN: 1047-3211- Author Web Link
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- Citations: 21
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Journal articleVijayan R, Scott G, 2013,
Doctor, interrupted
, British Medical Journal, Vol: 346, ISSN: 0007-1447
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