A list of projects from this CDT is available below.
Scott Lovell
Project: The KLK Activome: identifying new drug targets within a complex protein-protein interaction network
Euan Pyle
Project: An integrated structural biology approach for elucidating transient protein interactions
Michael Potter
Project: Liposome-based diagnostic and prognostic bio-sensing assay for quantifying the role of sphingomyelinase dysregulation in cardiovascular diseases and depression
Jasmine Bickel
Project: Novel adjuvants for antibody-based cancer therapeutics: design, biological characterization and influence on membrane-protein structure
Amina Jama
Project: Enhancing photosynthesis through molecular manipulation
Mark Wilkinson
Project: The mechanics of the eukaryotic actin protein-folding machinery from yeast to malaria
Richard Thistlethwaite
Project: Chemical probes to enable next-generation fungicides - preparing for the impact of climate change
Francesco Vianello
Project: A novel computational tool to reveal the all-scale structural organisation and design principles underpinning the activity of the enzyme responsible for the majority of global atmospheric CO2 fixation
Zainab Ahmed
Project: DELIVERY BY DESIGN: Increasing the efficiency of nucleic acids drug delivery in the cytosol using artificial/proto cells
Hugo Belda
Project: Functional analysis of kinases secreted into the host cell by the human malaria parasite Plasmodium falciparum
Giulia Campolo
Project: Real-time in sensing of dopamine and L-DOPA using DNA aptamers for improved Parkinson's disease therapies
Yee San (Eve) Chan
Project: Experimental detection of allosteric sites in proteins
Mohit Devgan
Project: Interaction of personal care formulations with skin mimetics
Ben Edwards
Project: Nanoscale Biosensors for Real-Time Analysis of Amyloid Proteins in Neurodegenerative Disease
Andrea Goya Grocin.
Project: Understanding dysregulation of protein lipidation in cancer CRUK PhD Studentship
Miha Homsak
Project: PLP-dependent chemoproteomics for identification and characterisation
Ryan Howard
Project: Investigating the target profile of a family of novel anti-cancer agents
Maeve Kavanagh
Project: Primary charge transfer in the Photosystem II reaction centre
Cassandra Kennedy
Project: Post-translational regulation of inflammation: chemical tools to probe dynamic protein modification during caspase activation and pyroptosis
Ben Lewis
Project: Imaging G-quadruplex DNA in live cells using FLIM
Suhuur Osman
Project: Multiplexed Single Cell analysis of small molecule stimulation of Epicardium Derived Cells (EPDCs)
Lucy Rowlands
Project: Novel Aptamer-Based Vesicle Drug-Delivery Systems
Carmel Ruehl
Project: Development of responsive optical probes for non-canonical nucleic acid structures
Pashiini Supramaniam
Project: Microfluidic Chip based Artificial Cells – a platform to control and understand biochemical signalling pathways
Shukai Wang
Project: Investigation of the structure and function of Vpu with all atom molecular dynamics simulations
Florian Song
Project: Unravelling G-quadruplex DNA dynamics through Markov Graph processes: a combined theoretical and experimental approach
Emma Woodcock
Project: Vesicles to build chemical libraries (template driven synthesis)
Simeon Draganov
Project: A mass spectometry and chemical biology approach to dissecting the molecular basis of Tissue Factor regulation via post-translational modifications of RNA-binding proteins
Liuba Dvinkikh
Project: Video-rate volumetric light sheet microscopy for studying the interaction of induced pluripotent stem cell derived cardiomyocytes with mature cardiac tissue
Callum Hay
Project: Developing artificial cells for delivering drug molecules to micro-engineered heart tissue
Miguel Paez Perez
Project: Imaging flow induced micromechanical changes in vascular endothelial cell membranes
Astrid Paul Lydia Stroobants
Project: Preeictive modeling of ICAM-1 repression by Erg; Designing therapeutic Erg mimetics using computational modelling
Alexander Swan
Project: Biophysical and structural characterisation of the interaction between the Popeye domain containing 1 (POPDC1) protein and small molecule ligands - towards a treatment for atrial fibrillation
Robert Strutt
Project: The development of novel molecular technologies for screening and understanding membrane interactions of proteolysis targeting chimeras (PROTACs)
Divya Malia
Project: Ineractions and structural effects in model membranes and triglycerides of molecules playing key roles in oxidation
Vanessa Ho
Project: Microfluidic Single Cell Analysis Technology incorporating single molecule detection for Non-Invasive Monitoring/Detection of Protein Changes in COPD Patients
Jenny Liu
Project: Development of novel methods that allow a mechanistic understanding of drivers of bio-membrane and barrier function disruption by concentrated detergents
Susannah Molisso
Project: Thermodynamics and Kinetics of Small Molecule Interactions with Biological Materials
Christopher Louis Parperis
Project: Imaging the mechanism of nanopore sensing
Manfredi San Germano
Project: Development of novel 3D cell culture system microfluidics plaform for drug screening and tissue engineering
Chiara Heidi
Project: Optimization of cell-free protein synthesis factories using CHO cell extracts
Delia Brustur
Project: Rab27: a novel target in cancer
Frances Collins
Project: Elucidating the role of carbon dioxide in the photosynthetic enzyme Ribulose-1, 5-Bisphosphate Carboxylase/ Oxygenase
Emma Couves
Project: Novel adjuvants for antibody-based cancer therapeutics: design, biological characterization and influence on membrane-protein structure.
Micol Damiani
Project: Osteopontin as a Diagnostic and Prognostic Biomarker in Biofluids for Cholangiocarcinoma
Helena Dodd
Project: Graphene oxide-templated biomolecular nanoclusters to control the Natural Killer cell anti-cancer response
Marco Esposito
Project: Organelle breeding for artificial cells
Ignacio Gispert Contamina
Project: Cells and organelles as embedded biomodules in artificial cells
Livia Kalossaka
Project: Functionally optimized biofilms for building façades
Borut Lampret
Project: Development of next-generation Bio-Printing
Qien Li
Project: Engineering novel cell mimetic membrane architectures
Denise Liano
Project: Understanding the role of G4 secondary structures in premature ageing disorders by biochemical, structural and genomic characterisation of the human CSB protein.
Joshua David Linfoot
Project: A Chemical Proteomic Workflow for Rapid Identification of Proteins Responsible for Metabolic Insecticide Resistance
Mike Lloyd
Project: Single Molecule Strategies for Studying Neurodegenerative Disease
Ana Losada de la Lastra
Project: A universal chemical proteomic platform to uncover the impact of dynamic protein S‐acylation in cancer
Thomas Pataillot-Meakin
Project: Improving prostate cancer prognosis via automated sampling and genomic analysis of circulating tumour DNA
Daisy Rogers-Simmonds
Project: Controlling nanopore loading in Droplet Interface Bilayers
Felix Thorsten Sheffield
Project: Novel techniques for high throughput membrane permeability assays in the agrochemical industry
Denise Thiel
Project: Tracking the metabolic footprints of cancer using context---dependent network analysis
Shaobin Zhang
Project: Exploiting asymmetry to generate new classes of biomaterials and artificial cells
Greta Zubaite
Project: Engineering biointerfaces between synthetic and biological cells
Frances Collins
Project: Elucidating the role of carbon dioxide in the photosynthetic enzyme Ribulose-1, 5-Bisphosphate Carboxylase/ Oxygenase: Towards enhancing photosynthesis
Alfred Gatehouse
Project: Cell free DNA size analysis using engineered hydrogel nanopore (EHN) sensors: a non-invasive diagnostic tool for cancer
Emmanuel Kanelos
Project: 3D Printing of Complex Neural Structures in synthetic biology derived scaffolds
Kerry O'Donnelly
Project: A novel CO2 detection and capturing tool for the study of the Functional interactome of carbonic anhydrase
Yuval Elani
Project: Microfluidic Platforms for Manufacturing Artificial Bilayer Networks and Screening Drug-Membrane Interactions
Angela de Manzanos.
Project: Development of a novel, generic chaperon assay to probe protein-protein AAA+ interactions: Theory and experiment in unison
Alastair Magness
Project: Diagnosing Cancer one Cell at a Time with Single Molecule Spectroscopy
Hugh Sowley
Project: Detection of binding and geometry determination of drug-protein interactions in a kinase binding site from EVV 2DIR Data
James Squires
Project: Single-cell chemical proteomics: understanding protein modification in health and disease
