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• Journal article
  Elani Y, Law RV, Ces O, 2015,

  Vesicle-based artificial cells: recent developments and prospects for drug delivery

  , THERAPEUTIC DELIVERY, Vol: 6, Pages: 541-543, ISSN: 2041-5990
  • Author Web Link
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  • Citations: 13
• Journal article
  Branch T, Girvan P, Barahona M, Ying Let al., 2015,

  Introduction of a Fluorescent Probe to Amyloid-β to Reveal Kinetic Insights into Its Interactions with Copper(II)

  , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 54, Pages: 1227-1230, ISSN: 1433-7851
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  • Citations: 40
• Journal article
  Barriga HMG, Booth P, Haylock S, Bazin R, Templer RH, Ces Oet al., 2014,

  Droplet interface bilayer reconstitution and activity measurement of the mechanosensitive channel of large conductance from Escherichia coli

  , Journal of the Royal Society Interface, Vol: 11, ISSN: 1742-5662

  Droplet interface bilayers (DIBs) provide an exciting new platform for the study of membrane proteins in stable bilayers of controlled composition. To date, the successful reconstitution and activity measurement of membrane proteins in DIBs has relied on the use of the synthetic lipid 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC). We report the functional reconstitution of the mechanosensitive channel of large conductance (MscL) into DIBs composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), a lipid of significantly greater biological relevance than DPhPC. MscL functionality has been demonstrated using a fluorescence-based assay, showing that dye flow occurs across the DIB when MscL is gated by the cysteine reactive chemical 2-(trimethylammonium)ethyl methane thiosulfonate bromide (MTSET). MscL has already been the subject of a number of studies investigating its interaction with the membrane. We propose that this method will pave the way for future MscL studies looking in detail at the effects of controlled composition or membrane asymmetry on MscL activity using biologically relevant lipids and will also be applicable to other lipid–protein systems, paving the way for the study of membrane proteins in DIBs with biologically relevant lipids.

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• Conference paper
  Walker RC, Dickson CJ, Madej BD, Skjevik AA, Betz RM, Teigen K, Gould IRet al., 2014,

  Amber lipid force field: Lipid14 and beyond

  , 248th National Meeting of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
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• Journal article
  Dickson CJ, Madej BD, Skjevik AA, Betz RM, Teigen K, Gould IR, Walker RCet al., 2014,

  Lipid14: The Amber Lipid Force Field

  , JOURNAL OF CHEMICAL THEORY AND COMPUTATION, Vol: 10, Pages: 865-879, ISSN: 1549-9618
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  • Citations: 868
• Conference paper
  Nickdel MB, Lagarto JL, Kelly DJ, Manning HB, Yamamoto K, Talbot CB, Dunsby C, French P, Itoh Yet al., 2014,

  Autofluorescence lifetime metrology for label-free detection of cartilage matrix degradation

  , Conference on Optical Biopsy XII, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
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• Conference paper
  Madej BD, Dickson CJ, Walker RC, Gould IRet al., 2013,

  Modular amber lipid force field for the simulation of complex membranes and membrane bound proteins

  , 245th National Meeting of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
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• Journal article
  Mak LH, Knott J, Scott KA, Scott C, Whyte GF, Ye Y, Mann DJ, Ces O, Stivers J, Woscholski Ret al., 2012,

  Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases

  , BIOORGANIC & MEDICINAL CHEMISTRY, Vol: 20, Pages: 4371-4376, ISSN: 0968-0896
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  • Citations: 11
• Journal article
  Wormit A, Butt SM, Chairam I, McKenna JF, Nunes-Nesi A, Kjaer L, O'Donnelly K, Fernie AR, Woscholski R, Barter MCL, Hamann Tet al., 2012,

  Osmosensitive Changes of Carbohydrate Metabolism in Response to Cellulose Biosynthesis Inhibition

  , PLANT PHYSIOLOGY, Vol: 159, Pages: 105-117, ISSN: 0032-0889
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  • Citations: 50
• Journal article
  Charalambous K, Booth PJ, Woscholski R, Seddon JM, Templer RH, Law RV, Barter LMC, Ces Oet al., 2012,

  Engineering <i>de Novo</i> Membrane-Mediated Protein-Protein Communication Networks

  , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 134, Pages: 5746-5749, ISSN: 0002-7863
  • Author Web Link
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  • Citations: 31

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