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@article{Kopniczky:2015:10.1109/TBCAS.2015.2451707,
author = {Kopniczky, M and moore, S and freemont, P},
doi = {10.1109/TBCAS.2015.2451707},
journal = {IEEE Transactions on Biomedical Circuits and Systems},
pages = {485--496},
title = {Multilevel regulation and translational switches in synthetic biology},
url = {http://dx.doi.org/10.1109/TBCAS.2015.2451707},
volume = {9},
year = {2015}
}
TY - JOUR
AB - In contrast to the versatility of regulatory mechanisms in natural systems, synthetic genetic circuits have been so far predominantly composed of transcriptionally regulated modules. This is about to change as the repertoire of foundational tools for post-transcriptional regulation is quickly expanding. We provide an overview of the different types of translational regulators: protein, small molecule and RNA responsive and we describe the new emerging circuit designs utilizing these tools. There are several advantages of achieving multilevel regulation via translational switches and it is likely that such designs will have the greatest and earliest impact in mammalian synthetic biology for regenerative medicine and gene therapy applications.
AU - Kopniczky,M
AU - moore,S
AU - freemont,P
DO - 10.1109/TBCAS.2015.2451707
EP - 496
PY - 2015///
SN - 1940-9990
SP - 485
TI - Multilevel regulation and translational switches in synthetic biology
T2 - IEEE Transactions on Biomedical Circuits and Systems
UR - http://dx.doi.org/10.1109/TBCAS.2015.2451707
UR - http://hdl.handle.net/10044/1/24561
VL - 9
ER -
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