BibTex format
@article{Zelina:2014:10.1016/j.neuron.2014.11.004,
author = {Zelina, P and Blockus, H and Zagar, Y and Peres, A and Friocourt, F and Wu, Z and Rama, N and Fouquet, C and Hohenester, E and Tessier-Lavigne, M and Schweitzer, J and Roest, Crollius H and Chedotal, A},
doi = {10.1016/j.neuron.2014.11.004},
journal = {Neuron},
pages = {1258--1272},
title = {Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution},
url = {http://dx.doi.org/10.1016/j.neuron.2014.11.004},
volume = {84},
year = {2014}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Development of neuronal circuits is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1, which mediates attraction through the DCC receptor. We discovered that the Robo3 receptor fundamentally changed its mechanism of action during mammalian evolution. Unlike other Robo receptors, mammalian Robo3 is not a high-affinity receptor for Slits because of specific substitutions in the first immunoglobulin domain. Instead, Netrin-1 selectively triggers phosphorylation of mammalian Robo3 via Src kinases. Robo3 does not bind Netrin-1 directly but interacts with DCC. Netrin-1 fails to attract pontine neurons lacking Robo3, and attraction can be restored in Robo3−/− mice by expression of mammalian, but not nonmammalian, Robo3. We propose that Robo3 evolution was key to sculpting the mammalian brain by converting a receptor for Slit repulsion into one that both silences Slit repulsion and potentiates Netrin attraction.
AU - Zelina,P
AU - Blockus,H
AU - Zagar,Y
AU - Peres,A
AU - Friocourt,F
AU - Wu,Z
AU - Rama,N
AU - Fouquet,C
AU - Hohenester,E
AU - Tessier-Lavigne,M
AU - Schweitzer,J
AU - Roest,Crollius H
AU - Chedotal,A
DO - 10.1016/j.neuron.2014.11.004
EP - 1272
PY - 2014///
SN - 0896-6273
SP - 1258
TI - Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution
T2 - Neuron
UR - http://dx.doi.org/10.1016/j.neuron.2014.11.004
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346574500017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://www.sciencedirect.com/science/article/pii/S0896627314010046?via%3Dihub
VL - 84
ER -
