BibTex format
@inproceedings{Cota:2011,
author = {Cota, E},
pages = {149--151},
title = {Als adhesins - Structural basis for the broad specificity to host-cell ligands by Candida albicans},
year = {2011}
}
Citation
RIS format (EndNote, RefMan)
TY - CPAPER
AB - Als (agglutinin-like sequence) glycoproteins have been associated with binding of host-cell surface proteins and small peptides of random sequence, the formation of biofilms and amyloid fibers. High-resolution structures of N-terminal Als domains show that ligand recognition relies on a motif capable of binding flexible C termini of peptides in extended conformation. These data establish NT-Als adhesins as a separate family of peptide-binding proteins and an unexpected adhesion system for primary, widespread protein–protein interactions at the Candida/host-cell interface. The new structural information also provides potential templates for the design of novel antifungals.
AU - Cota,E
EP - 151
PY - 2011///
SP - 149
TI - Als adhesins - Structural basis for the broad specificity to host-cell ligands by Candida albicans
ER -
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