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• Journal article
  Wigneshweraraj S, Bose D, Burrows PC, Joly N, Schumacher J, Rappas M, Pape T, Zhang X, Stockley P, Severinov K, Buck Met al., 2008,

  <i>Modus operandi</i> of the bacterial RNA polymerase containing the σ<SUP>54</SUP> promoter-specificity factor

  , MOLECULAR MICROBIOLOGY, Vol: 68, Pages: 538-546, ISSN: 0950-382X
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  • Citations: 101
• Journal article
  Squire JM, Knupp C, Luther PK, 2008,

  Zebrafish - Topical, transparent, and tractable for ultrastructural studies

  , JOURNAL OF GENERAL PHYSIOLOGY, Vol: 131, Pages: 439-443, ISSN: 0022-1295
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  • Citations: 4
• Journal article
  Hohenester E, 2008,

  Structural insight into Slit-Robo signalling

  , BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 36, Pages: 251-256, ISSN: 0300-5127
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  • Citations: 76
• Journal article
  Barber J, Murray JW, 2008,

  The structure of the Mn₄Ca<SUP>2+</SUP> cluster of photosystem II and its protein environment as revealed by X-ray crystallography

  , PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 363, Pages: 1129-1137, ISSN: 0962-8436
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  • Citations: 46
• Journal article
  Boussac A, Sugiura M, Lai T-L, Rutherford AWet al., 2008,

  Low-temperature photochemistry in photosystem II from <i>Thermosynechococcus elongatus</i> induced by visible and near-infrared light

  , PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 363, Pages: 1203-1210, ISSN: 0962-8436
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  • Citations: 32
• Journal article
  Barber J, Rutherford AW, 2008,

  Introduction

  , PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 363, Pages: 1125-1128, ISSN: 0962-8436
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  • Citations: 4
• Journal article
  Carafoli F, Saffell JL, Hohenester E, 2008,

  Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule

  , JOURNAL OF MOLECULAR BIOLOGY, Vol: 377, Pages: 524-534, ISSN: 0022-2836
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  • Citations: 31
• Journal article
  Adams JC, Bentley AA, Kvansakul M, Hatherley D, Hohenester Eet al., 2008,

  Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region

  , JOURNAL OF CELL SCIENCE, Vol: 121, Pages: 784-795, ISSN: 0021-9533
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  • Citations: 38
• Journal article
  Konitsiotis AD, Raynal N, Bihan D, Hohenester E, Farndale RW, Leitinger Bet al., 2008,

  Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen

  , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 6861-6868, ISSN: 0021-9258
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  • Citations: 158
• Journal article
  Engelman A, Cherepanov P, 2008,

  The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

  , PLOS PATHOGENS, Vol: 4, ISSN: 1553-7366
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  • Citations: 182
• Journal article
  Frankel G, Phillips AD, 2008,

  Attaching effacing <i>Escherichia coli</i> and paradigms of Tir-triggered actin polymerization:: getting off the pedestal

  , CELLULAR MICROBIOLOGY, Vol: 10, Pages: 549-556, ISSN: 1462-5814
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  • Citations: 130
• Journal article
  De Simone A, Pedone C, Vitagliano L, 2008,

  Structure, dynamics, and stability of assemblies of the human prion fragment SNQNNF

  , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 366, Pages: 800-806, ISSN: 0006-291X
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  • Citations: 14
• Journal article
  Colombo G, Meli M, De Simone A, 2008,

  Computational studies of the structure, dynamics and native content of amyloid-like fibrils of ribonuclease A

  , PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, Vol: 70, Pages: 863-872, ISSN: 0887-3585
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  • Citations: 16
• Journal article
  Mazurkiewicz P, Thomas J, Thompson JA, Liu M, Arbibe L, Sansonetti P, Holden DWet al., 2008,

  SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases

  , Molecular Microbiology, Vol: 67, Pages: 1371-1383, ISSN: 1365-2958

  SpvC is encoded by the Salmonella virulence plasmid. We have investigated the biochemical function of SpvC and the mechanism by which it is secreted by bacteria and translocated into infected macrophages. We constructed a strain carrying a deletion in spvC and showed that the strain is attenuated for systemic virulence in mice. SpvC can be secreted in vitro by either the SPI-1 or SPI-2 type III secretion systems. Cell biological and genetic experiments showed that translocation of the protein into the cytosol of macrophages by intracellular bacteria is dependent on the SPI-2 T3SS. Using antibodies specific to phospho-amino acids and mass spectrometry we demonstrate that SpvC has phosphothreonine lyase activity on full-length phospho-Erk (pErk) and a synthetic 13-amino-acid phospho-peptide containing the TXY motif. A Salmonella strain expressing spvC from a plasmid downregulated cytokine release from infected cells.

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• Journal article
  Vardakou M, Dumon C, Murray JW, Christakopoulos P, Weiner DP, Juge N, Lewis RJ, Gilbert HJ, Flint JEet al., 2008,

  Understanding the structural basis for substrate and inhibitor recognition in eukaryotic GH11 xylanases

  , JOURNAL OF MOLECULAR BIOLOGY, Vol: 375, Pages: 1293-1305, ISSN: 0022-2836
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  • Citations: 86
• Journal article
  Herrero C, Lassalle-Kaiser B, Leibl W, Rutherford AW, Aukauloo Aet al., 2008,

  Artificial systems related to light driven electron transfer processes in PSII

  , COORDINATION CHEMISTRY REVIEWS, Vol: 252, Pages: 456-468, ISSN: 0010-8545
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  • Citations: 89
• Journal article
  Barber J, Murray JW, 2008,

  Revealing the structure of the Mn-cluster of photosystem 11 by X-ray crystallography

  , COORDINATION CHEMISTRY REVIEWS, Vol: 252, Pages: 233-243, ISSN: 0010-8545
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  • Citations: 65
• Journal article
  Yeung HO, Kloppsteck P, Niwa H, Isaacson RL, Matthews S, Zhang X, Freemont PSet al., 2008,

  Insights into adaptor binding to the AAA protein p97

  , BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 36, Pages: 62-67, ISSN: 0300-5127
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  • Citations: 107
• Journal article
  Burgoyne T, Muhamed F, Luther PK, 2008,

  Visualisation of cardiac muscle thin filaments and measurement of their lengths by electron tomography

  , Cardiovascular Research
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• Journal article
  Bai L, Schuller S, Whale A, Mousnier A, Marches O, Wang L, Ooka T, Heuschkel R, Torrente F, Kaper JB, Gomes TAT, Xu J, Phillips AD, Frankel Get al., 2008,

  Enteropathogenic <i>Escherichia coli</i> O125:H6 triggers attaching and effacing lesions on human intestinal biopsy specimens independently of nck and TccP/TccP2

  , INFECTION AND IMMUNITY, Vol: 76, Pages: 361-368, ISSN: 0019-9567
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  • Citations: 32
• Journal article
  Baldwin GS, Brooks NJ, Robson RE, Wynveen A, Goldar A, Leikin S, Seddon JM, Kornyshev AAet al., 2008,

  DNA double helices recognize mutual sequence homology in a protein free environment

  , J. Phys. Chem. B, Vol: 112, Pages: 1060-1064
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• Journal article
  van Thor JJ, Ronayne KL, Towrie M, Sage JTet al., 2008,

  Balance between parallel ultrafast excited state proton transfer reactions in GFP has a structural origin.

  , Biophys J, Vol: 95, Pages: 1902-1912

  The fluorescence photocycle of the green fluorescent protein is functionally dependent on the specific structural protein environment. A direct relationship between equilibrium protein side-chain conformation of glutamate 222 and reactivity is established, particularly the rate of ultrafast proton transfer reactions in the fluorescence photocycle. We show that parallel transformations in the photocycle have a structural origin, and we report on the vibrational properties of responsive amino acids on an ultrafast timescale. Blue excitation of GFP drives two parallel, excited-state deuteron transfer reactions with 10 ps and 75 ps time constants to the buried carboxylic acid side chain of glutamate 222 via a hydrogen-bonding network. Assignment of 1456 cm(-1) and 1441 cm(-1) modes to nu(sym) and assignment of 1564 cm(-1) and 1570 cm(-1) features to nu(asym) of E222 in the 10 ps and 75 ps components, respectively, was possible from the analysis of the transient absorption data of an E222D mutant and was consistent with photoselection measurements. In contrast to the wild-type, measurements of E222D can be described with only one difference spectrum, with the nu(sym) mode at 1435 cm(-1) and the nu(asym) mode at 1567 cm(-1), also correlating a large Deltanu(asym-sym) with slow excited-state proton transfer kinetics. Density Functional Theory calculations and published model compound and theoretical studies relate differences in Deltanu(asym-sym) to the strength and number of hydrogen-bonding interactions that are detected via equilibrium geometry and COO- stretching frequency differences of the carboxylate. The correlation of photocycle kinetics with side-chain conformation of the acceptor suggests that proton transfer from S205 to E222 controls the rate of the overall excited-state proton transfer process, which is consistent with recent theoretical predictions. Photoselection measurements show agreement for localized C=O vibrations of chromophore, Q69, and E222 with Den

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• Journal article
  Millson SH, Vaughan CK, Zhai C, Ali MM, Panaretou B, Piper PW, Pearl LH, Prodromou Cet al., 2008,

  Chaperone ligand-discrimination by the TPR-domain protein Tah1

  , Biochem J, Pages: 261-268
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