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• Journal article
  Bialek W, Wen S, Michoux F, Beckova M, Komenda J, Murray JW, Nixon PJet al., 2013,

  Crystal structure of the Psb28 accessory factor of <i>Thermosynechococcus elongatus</i> photosystem II at 2.3 Å

  , PHOTOSYNTHESIS RESEARCH, Vol: 117, Pages: 375-383, ISSN: 0166-8595
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  • Citations: 8
• Journal article
  Mercedes Palomino M, Allievi MC, Gruendling A, Sanchez-Rivas C, Ruzal SMet al., 2013,

  Osmotic stress adaptation in <i>Lactobacillus casei</i> BL23 leads to structural changes in the cell wall polymer lipoteichoic acid

  , MICROBIOLOGY-SGM, Vol: 159, Pages: 2416-2426, ISSN: 1350-0872
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  • Citations: 34
• Journal article
  Bebeacua C, Tremblay D, Farenc C, Chapot-Chartier M-P, Sadovskaya I, van Heel M, Veesler D, Moineau S, Cambillau Cet al., 2013,

  Structure, Adsorption to Host, and Infection Mechanism of Virulent Lactococcal Phage p2

  , JOURNAL OF VIROLOGY, Vol: 87, Pages: 12302-12312, ISSN: 0022-538X
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  • Citations: 70
• Journal article
  Harding CR, Mattheis C, Mousnier A, Oates CV, Hartland EL, Frankel G, Schroeder GNet al., 2013,

  LtpD Is a Novel <i>Legionella pneumophila</i> Effector That Binds Phosphatidylinositol 3-Phosphate and Inositol Monophosphatase IMPA1

  , INFECTION AND IMMUNITY, Vol: 81, Pages: 4261-4270, ISSN: 0019-9567
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  • Citations: 28
• Journal article
  Lai Y, Rosenshine I, Leong JM, Frankel Get al., 2013,

  Intimate host attachment: enteropathogenic and enterohaemorrhagic <i>Escherichia coli</i>

  , CELLULAR MICROBIOLOGY, Vol: 15, Pages: 1796-1808, ISSN: 1462-5814
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  • Citations: 81
• Journal article
  Bertheleme N, Chae PS, Singh S, Mossakowska D, Hann MM, Smith KJ, Hubbard JA, Dowell SJ, Byrne Bet al., 2013,

  Unlocking the secrets of the gatekeeper: Methods for stabilizing and crystallizing GPCRs

  , BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Vol: 1828, Pages: 2583-2591, ISSN: 0005-2736
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  • Citations: 28
• Journal article
  Quigley A, Heng JYY, Liddell JM, Williams DRet al., 2013,

  The accurate measurement of second virial coefficients using self-interaction chromatography: Experimental considerations

  , EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Vol: 85, Pages: 1103-1111, ISSN: 0939-6411
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  • Citations: 11
• Journal article
  Casini A, MacDonald JT, De Jonghe J, Christodoulou G, Freemont PS, Baldwin GS, Ellis Tet al., 2013,

  One-pot DNA construction for synthetic biology: the Modular Overlap-Directed Assembly with Linkers (MODAL) strategy

  , Nucleic Acids Research, Vol: 42, ISSN: 1362-4962

  Overlap-directed DNA assembly methods allowmultiple DNA parts to be assembled together inone reaction. These methods, which rely onsequence homology between the ends of DNAparts, have become widely adopted in syntheticbiology, despite being incompatible with a key principleof engineering: modularity. To answer this, wepresent MODAL: a Modular Overlap-DirectedAssembly with Linkers strategy that brings modularityto overlap-directed methods, allowing assemblyof an initial set of DNA parts into a variety ofarrangements in one-pot reactions. MODAL isaccompanied by a custom software tool thatdesigns overlap linkers to guide assembly,allowing parts to be assembled in any specifiedorder and orientation. The in silico design of syntheticorthogonal overlapping junctions allows formuch greater efficiency in DNA assembly for avariety of different methods compared with usingnon-designed sequence. In tests with three differentassembly technologies, the MODAL strategy givesassembly of both yeast and bacterial plasmids,composed of up to five DNA parts in the kilobaserange with efficiencies of between 75 and 100%.It also seamlessly allows mutagenesis to beperformed on any specified DNA parts duringthe process, allowing the one-step creation of constructlibraries valuable for synthetic biologyapplications.

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• Journal article
  Sethurathinam S, Singh LP, Panneerselvam P, Byrne B, Ding JLet al., 2013,

  UXT plays dual opposing roles on SARM-induced apoptosis

  , FEBS LETTERS, Vol: 587, Pages: 3296-3302, ISSN: 0014-5793
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  • Citations: 12
• Journal article
  Gruendling A, 2013,

  Potassium Uptake Systems in <i>Staphylococcus aureus</i>: New Stories about Ancient Systems

  , MBIO, Vol: 4, ISSN: 2150-7511
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  • Citations: 33
• Journal article
  Solomon HV, Tabachnikov O, Feinberg H, Govada L, Chayen NE, Shoham Y, Shoham Get al., 2013,

  Crystallization and preliminary crystallographic analysis of GanB, a GH42 intracellular β-galactosidase from <i>Geobacillus stearothermophilus</i>

  , ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, Vol: 69, Pages: 1114-1119
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  • Citations: 19
• Journal article
  Carafoli F, Hohenester E, 2013,

  Collagen recognition and transmembrane signalling by discoidin domain receptors

  , BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, Vol: 1834, Pages: 2187-2194, ISSN: 1570-9639
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  • Citations: 71
• Journal article
  Canning P, Cooper CDO, Krojer T, Murray JW, Pike ACW, Chaikuad A, Keates T, Thangaratnarajah C, Hojzan V, Ayinampudi V, Marsden BD, Gileadi O, Knapp S, von Delft F, Bullock ANet al., 2013,

  Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases (vol 288, pg 7803, 2013)

  , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 288, Pages: 28304-28304
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• Journal article
  De Simone A, Gustavsson M, Montalvao RW, Shi L, Veglia G, Vendruscoo Met al., 2013,

  Structures of the Excited States of Phospholamban and Shifts in Their Populations upon Phosphorylation

  , BIOCHEMISTRY, Vol: 52, Pages: 6684-6694, ISSN: 0006-2960
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  • Citations: 21
• Journal article
  Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Franks NPet al., 2013,

  A propofol binding site on mammalian GABAA receptors identified by photolabeling

  , Nature Chemical Biology, Vol: 9, Pages: 715-720, ISSN: 1552-4469

  Propofol is the most important intravenous general anesthetic in current clinical use. It acts by potentiating GABAA (γ-aminobutyric acid type A) receptors, but where it binds to this receptor is not known and has been a matter of some debate. We synthesized a new propofol analog photolabeling reagent whose biological activity is very similar to that of propofol. We confirmed that this reagent labeled known propofol binding sites in human serum albumin that have been identified using X-ray crystallography. Using a combination of protiated and deuterated versions of the reagent to label mammalian receptors in intact membranes, we identified a new binding site for propofol in GABAA receptors consisting of both β3 homopentamers and α1β3 heteropentamers. The binding site is located within the β subunit at the interface between the transmembrane domains and the extracellular domain and lies close to known determinants of anesthetic sensitivity in the transmembrane segments TM1 and TM2.

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• Journal article
  Pearson JS, Giogha C, Ong SY, Kennedy CL, Kelly M, Robinson KS, Lung TWF, Mansell A, Riedmaier P, Oates CVL, Zaid A, Muehlen S, Crepin VF, Marches O, Ang C-S, Williamson NA, O'Reilly LA, Bankovacki A, Nachbur U, Infusini G, Webb AI, Silke J, Strasser A, Frankel G, Hartland ELet al., 2013,

  A type III effector antagonizes death receptor signalling during bacterial gut infection

  , NATURE, Vol: 501, Pages: 247-+, ISSN: 0028-0836
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  • Citations: 206
• Journal article
  Reichmann NT, Cassona CP, Gruendling A, 2013,

  Revised mechanism of D-alanine incorporation into cell wall polymers in Gram-positive bacteria

  , MICROBIOLOGY-SGM, Vol: 159, Pages: 1868-1877, ISSN: 1350-0872
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  • Citations: 69
• Journal article
  Choudhury HG, Beis K, 2013,

  The dimeric form of the unphosphorylated response regulator BaeR

  , PROTEIN SCIENCE, Vol: 22, Pages: 1287-1293, ISSN: 0961-8368
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  • Citations: 11
• Journal article
  Saridakis E, Chayen NE, 2013,

  Imprinted polymers assisting protein crystallization

  , TRENDS IN BIOTECHNOLOGY, Vol: 31, Pages: 515-520, ISSN: 0167-7799
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  • Citations: 41
• Journal article
  Squire JM, Guerreiro MJ, Sidebotham RL, Reis CA, Wiseman J, Luther PKet al., 2013,

  Quantitative MUC5AC and MUC6 mucin estimations in gastric mucus by a least-squares minimization method

  , ANALYTICAL BIOCHEMISTRY, Vol: 439, Pages: 204-211, ISSN: 0003-2697
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  • Citations: 3
• Journal article
  Moore BL, Kelley LA, Barber J, Murray JW, MacDonald JTet al., 2013,

  High-quality protein backbone reconstruction from alpha carbons using gaussian mixture models

  , JOURNAL OF COMPUTATIONAL CHEMISTRY, Vol: 34, Pages: 1881-1889, ISSN: 0192-8651
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  • Citations: 42
• Journal article
  Filloux A, 2013,

  MICROBIOLOGY A weapon for bacterial warfare

  , NATURE, Vol: 500, Pages: 284-285, ISSN: 0028-0836
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  • Citations: 7
• Journal article
  Krupnik T, Kotabova E, van Bezouwen LS, Mazur R, Garstka M, Nixon PJ, Barber J, Kana R, Boekema EJ, Kargul Jet al., 2013,

  A Reaction Center-dependent Photoprotection Mechanism in a Highly Robust Photosystem II from an Extremophilic Red Alga, <i>Cyanidioschyzon merolae</i>

  , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 288, Pages: 23529-23542, ISSN: 0021-9258
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  • Citations: 47
• Journal article
  Mikkelsen H, Hui K, Barraud N, Filloux Aet al., 2013,

  The pathogenicity island encoded PvrSR/RcsCB regulatory network controls biofilm formation and dispersal in Pseudomonas aeruginosa PA14

  , Molecular Microbiology, Vol: 89, Pages: 450-463, ISSN: 0950-382X

  Pseudomonas aeruginosa biofilm formation is linked to persistent infections in humans. Biofilm formation is facilitated by extracellular appendages, some of which are assembled by the Chaperone Usher Pathway (Cup). The cupD gene cluster is located on the PAPI‐1 pathogenicity island of strain PA14 and has probably been acquired together with four genes encoding two‐component signal transduction proteins. We have previously showed that the RcsB response regulator activates expression of the cupD genes, which leads to the production of CupD fimbriae and increased attachment. Here we show that RcsB activity is tightly modulated by two sensors, RcsC and PvrS. While PvrS acts as a kinase that enhances RcsB activity, RcsC has a dual function, first as a phosphorelay, and second as a phosphatase. We found that, under certain growth conditions, overexpression of RcsB readily induces biofilm dispersal. Microarray analysis shows that RcsB positively controls expression of pvrR that encodes the phosphodiesterase required for this dispersal process. Finally, in addition to the PAPI‐1 encoded cupD genes, RcsB controls several genes on the core genome, some of which encode orphan response regulators. We thus discovered that RcsB is central to a large regulatory network that fine‐tunes the switch between biofilm formation and dispersal.

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• Journal article
  Corrigan RM, Gruendling A, 2013,

  Cyclic di-AMP: another second messenger enters the fray

  , NATURE REVIEWS MICROBIOLOGY, Vol: 11, Pages: 513-524, ISSN: 1740-1526
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  • Citations: 259
• Journal article
  Raymond B, Young JC, Pallett M, Endres RG, Clements A, Frankel Get al., 2013,

  Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors

  , TRENDS IN MICROBIOLOGY, Vol: 21, Pages: 430-439, ISSN: 0966-842X
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  • Citations: 98
• Journal article
  Carafoli F, Hamaia SW, Bihan D, Hohenester E, Farndale RWet al., 2013,

  An Activating Mutation Reveals a Second Binding Mode of the Integrin α2 I Domain to the GFOGER Motif in Collagens

  , PLOS ONE, Vol: 8, ISSN: 1932-6203
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  • Citations: 26
• Journal article
  Kato M, Cardona T, Rutherford AW, Reisner Eet al., 2013,

  Covalent Immobilization of Oriented Photosystem II on a Nanostructured Electrode for Solar Water Oxidation

  , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 135, Pages: 10610-10613, ISSN: 0002-7863
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  • Citations: 98
• Journal article
  Zhu M, De Simone A, Schenk D, Toth G, Dobson CM, Vendruscolo Met al., 2013,

  Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide

  , JOURNAL OF CHEMICAL PHYSICS, Vol: 139, ISSN: 0021-9606
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  • Citations: 65
• Journal article
  Santos AJM, Meinecke M, Fessler MB, Holden DW, Boucrot Eet al., 2013,

  Preferential invasion of mitotic cells by Salmonella reveals that cell surface cholesterol is maximal during metaphase

  , JOURNAL OF CELL SCIENCE, Vol: 126, Pages: 2990-2996, ISSN: 0021-9533
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  • Citations: 29

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