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• Journal article
  Fagan RP, Fairweather NF, 2014,

  Biogenesis and functions of bacterial S-layers

  , NATURE REVIEWS MICROBIOLOGY, Vol: 12, Pages: 211-222, ISSN: 1740-1526
  • Author Web Link
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  • Citations: 226
• Journal article
  Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang J-P, Brown EM, Frankel G, Levy M, Katz MN, Philbrick WM, Elinav E, Finlay BB, Flavell RAet al., 2014,

  NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

  , CELL, Vol: 156, Pages: 1045-1059, ISSN: 0092-8674
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  • Citations: 487
• Journal article
  Dionne MS, 2014,

  Immune-metabolic interaction in <i>Drosophila</i>

  , FLY, Vol: 8, Pages: 75-79, ISSN: 1933-6934
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  • Citations: 21
• Journal article
  Gouzy A, Larrouy-Maumus G, Bottai D, Levillain F, Dumas A, Wallach JB, Caire-Brandli I, de Chastellier C, Wu T-D, Poincloux R, Brosch R, Guerquin-Kern J-L, Schnappinger D, de Carvalho LPS, Poquet Y, Neyrolles Oet al., 2014,

  <i>Mycobacterium tuberculosis</i> Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection

  , PLOS PATHOGENS, Vol: 10, ISSN: 1553-7366
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  • Citations: 114
• Journal article
  Rudkin JK, Laabei M, Edwards AM, Joo H-S, Otto M, Lennon KL, O'Gara JP, Waterfield NR, Massey RCet al., 2014,

  Oxacillin Alters the Toxin Expression Profile of Community-Associated Methicillin-Resistant <i>Staphylococcus aureus</i>

  , ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol: 58, Pages: 1100-1107, ISSN: 0066-4804
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  • Citations: 44
• Journal article
  Sampson SL, Saraiva L, Gustafsson K, Jayasinghe SN, Robertson BDet al., 2014,

  Cell Electrospinning: An In Vitro and In Vivo Study

  , Small, Vol: 10, Pages: 78-82, ISSN: 1613-6810

  Cell electrospinning and aerodynamically assisted bio-threading are novel bioplatforms for directly forming large quantities of cell-laden scaffolds for creating living sheets and vessels in three-dimensions. The functional biological architectures generated will be useful in both the laboratory and the clinic.

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• Journal article
  Larrouy-Maumus G, Kelly G, de Carvalho LPS, 2014,

  Chemical Mechanism of Glycerol 3-Phosphate Phosphatase: pH-Dependent Changes in the Rate-Limiting Step

  , BIOCHEMISTRY, Vol: 53, Pages: 143-151, ISSN: 0006-2960
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  • Citations: 1
• Journal article
  Helaine S, Cheverton AM, Watson KG, Faure LM, Matthews SA, Holden DWet al., 2014,

  Internalization of salmonella by macrophages induces formation of nonreplicating persisters

  , SCIENCE, Vol: 343, Pages: 204-208, ISSN: 0036-8075

  Many bacterial pathogens cause persistent infections despite repeated antibiotic exposure. Bacterial persisters are antibiotic-tolerant cells, but little is known about their growth status and the signals and pathways leading to their formation in infected tissues. We used fluorescent single-cell analysis to identify Salmonella persisters during infection. These were part of a nonreplicating population formed immediately after uptake by macrophages and were induced by vacuolar acidification and nutritional deprivation, conditions that also induce Salmonella virulence gene expression. The majority of 14 toxin-antitoxin modules contributed to intracellular persister formation. Some persisters resumed intracellular growth after phagocytosis by naïve macrophages. Thus, the vacuolar environment induces phenotypic heterogeneity, leading to either bacterial replication or the formation of nonreplicating persisters that could provide a reservoir for relapsing infection.

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• Journal article
  Liu B, Shadrin A, Sheppard C, Mekler V, Xu Y, Severinov K, Matthews S, Wigneshweraraj Set al., 2014,

  The sabotage of the bacterial transcription machinery by a small bacteriophage protein.

  , Bacteriophage, Vol: 4, ISSN: 2159-7073

  Many bacteriophages produce small proteins that specifically interfere with the bacterial host transcription machinery and thus contribute to the acquisition of the bacterial cell by the bacteriophage. We recently described how a small protein, called P7, produced by the Xp10 bacteriophage inhibits bacterial transcription initiation by causing the dissociation of the promoter specificity sigma factor subunit from the host RNA polymerase holoenzyme. In this addendum to the original publication, we present the highlights of that research.

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• Journal article
  Clark RI, Walker DW, Dionne MS, 2014,

  Metabolic and immune integration in aging and age-related disease

  , AGING-US, Vol: 6, Pages: 3-4, ISSN: 1945-4589
  • Author Web Link
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  • Citations: 6

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