In this section
@article{Sanchez:2021:10.1016/j.mib.2021.08.008,
author = {Sanchez, Garrido J and Alberdi, L and Chatterjee, S and Frankel, G and Mullineaux-Sanders, C},
doi = {10.1016/j.mib.2021.08.008},
journal = {Current Opinion in Microbiology},
pages = {19--26},
title = {Type III secretion system effector subnetworks elicit distinct host immune responses to infection},
url = {http://dx.doi.org/10.1016/j.mib.2021.08.008},
volume = {64},
year = {2021}
}
TY - JOUR
AB - Citrobacter rodentium, a natural mouse pathogen which colonises the colon of immuno-competent mice, provides a robust model for interrogating host-pathogen-microbiota interactions in vivo. This model has been key to providing new insights into local host responses to enteric infection, including changes inintestinal epithelial cell immuno metabolism and mucosal immunity. C. rodent iuminjects 31 bacterial effectors into epithelial cells via a type III secretion system (T3SS). Recently, these effectors were shown to be able to form multiple intracellular subnetworks which can withstand significant contractions whilst maintaining virulence. Here we highlight recent advances in understanding gut mucosal responses to infection and effector biology, as well as potential uses for artificial intelligence (AI) in understanding infectious diseaseand speculate on the role of T3SS effector networks in host adaption.
AU - Sanchez,Garrido J
AU - Alberdi,L
AU - Chatterjee,S
AU - Frankel,G
AU - Mullineaux-Sanders,C
DO - 10.1016/j.mib.2021.08.008
EP - 26
PY - 2021///
SN - 1369-5274
SP - 19
TI - Type III secretion system effector subnetworks elicit distinct host immune responses to infection
T2 - Current Opinion in Microbiology
UR - http://dx.doi.org/10.1016/j.mib.2021.08.008
UR - http://hdl.handle.net/10044/1/91777
VL - 64
ER -
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