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@article{Humphrey:2021:10.1038/s41467-021-26004-5,
author = {Humphrey, S and Fillol-Salom, A and Quiles-Puchalt, N and Ibarra-Chávez, R and Haag, A and Chen, J and Penades, J},
doi = {10.1038/s41467-021-26004-5},
journal = {Nature Communications},
pages = {1--12},
title = {Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements},
url = {http://dx.doi.org/10.1038/s41467-021-26004-5},
volume = {12},
year = {2021}
}
TY - JOUR
AB - It is commonly assumed that the horizontal transfer of most bacterial chromosomal genes is limited, in contrast to the frequent transfer observed for typical mobile genetic elements. However, this view has been recently challenged by the discovery of lateral transduction in Staphylococcus aureus, where temperate phages can drive the transfer of large chromosomalregions at extremely high frequencies. Here, we analyse previously published as well as new datasets to compare horizontal gene transfer rates mediated by different mechanisms in S. aureus and Salmonella enterica. We find that the horizontal transfer of core chromosomal genes via lateral transduction can be more efficient than the transfer of classical mobile genetic elements via conjugation or generalized transduction. These results raise questions about our definition of mobile genetic elements, and the potential roles played by lateral transduction in bacterial evolution.
AU - Humphrey,S
AU - Fillol-Salom,A
AU - Quiles-Puchalt,N
AU - Ibarra-Chávez,R
AU - Haag,A
AU - Chen,J
AU - Penades,J
DO - 10.1038/s41467-021-26004-5
EP - 12
PY - 2021///
SN - 2041-1723
SP - 1
TI - Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/s41467-021-26004-5
UR - https://www.nature.com/articles/s41467-021-26004-5
UR - http://hdl.handle.net/10044/1/91588
VL - 12
ER -
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