BibTex format
@article{Rao:2021:10.1038/s41598-021-83755-3,
author = {Rao, KU and Henderson, DI and Krishnan, N and Puthia, M and Glegola-Madejska, I and Brive, L and Bjarnemark, F and Fureby, AM and Hjort, K and Andersson, DI and Tenland, E and Sturegard, E and Robertson, BD and Godaly, G},
doi = {10.1038/s41598-021-83755-3},
journal = {Scientific Reports},
title = {A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy},
url = {http://dx.doi.org/10.1038/s41598-021-83755-3},
volume = {11},
year = {2021}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Alternative ways to prevent and treat infectious diseases are needed. Previously, we identified a fungal peptide, NZX, that was comparable to rifampicin in lowering M. tuberculosis load in a murine tuberculosis (TB) infection model. Here we assessed the potential synergy between this cationic host defence peptide (CHDP) and the current TB drugs and analysed its pharmacokinetics. We found additive effect of this peptide with isoniazid and ethambutol and confirmed these results with ethambutol in a murine TB-model. In vivo, the peptide remained stable in circulation and preserved lung structure better than ethambutol alone. Antibiotic resistance studies did not induce mutants with reduced susceptibility to the peptide. We further observed that this peptide was effective against nontuberculous mycobacteria (NTM), such as M. avium and M. abscessus, and several Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. In conclusion, the presented data supports a role for this CHDP in the treatment of drug resistant organisms.
AU - Rao,KU
AU - Henderson,DI
AU - Krishnan,N
AU - Puthia,M
AU - Glegola-Madejska,I
AU - Brive,L
AU - Bjarnemark,F
AU - Fureby,AM
AU - Hjort,K
AU - Andersson,DI
AU - Tenland,E
AU - Sturegard,E
AU - Robertson,BD
AU - Godaly,G
DO - 10.1038/s41598-021-83755-3
PY - 2021///
SN - 2045-2322
TI - A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy
T2 - Scientific Reports
UR - http://dx.doi.org/10.1038/s41598-021-83755-3
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000621416400074&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://www.nature.com/articles/s41598-021-83755-3
UR - http://hdl.handle.net/10044/1/87879
VL - 11
ER -
