BibTex format
@article{van:2021:10.15252/embj.2020106103,
author = {van, Sorge NM and Bonsor, DA and Deng, L and Lindahl, E and Schmitt, V and Lyndin, M and Schmidt, A and Nilsson, OR and Brizuela, J and Boero, E and Sundberg, EJ and van, Strijp JAG and Doran, KS and Singer, BB and Lindahl, G and McCarthy, AJ},
doi = {10.15252/embj.2020106103},
journal = {The EMBO Journal},
pages = {1--20},
title = {Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors},
url = {http://dx.doi.org/10.15252/embj.2020106103},
volume = {40},
year = {2021}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Streptococcus agalactiae, also known as group B Streptococcus (GBS), is the major cause of neonatal sepsis in humans. A critical step to infection is adhesion of bacteria to epithelial surfaces. GBS adhesins have been identified to bind extracellular matrix components and cellular receptors. However, several putative adhesins have no host binding partner characterised. We report here that surface-expressed β protein of GBS binds to human CEACAM1 and CEACAM5 receptors. A crystal structure of the complex showed that an IgSF domain in β represents a novel Ig-fold subtype called IgI3, in which unique features allow binding to CEACAM1. Bioinformatic assessment revealed that this newly identified IgI3 fold is not exclusively present in GBS but is predicted to be present in adhesins from other clinically important human pathogens. In agreement with this prediction, we found that CEACAM1 binds to an IgI3 domain found in an adhesin from a different streptococcal species. Overall, our results indicate that the IgI3 fold could provide a broadly applied mechanism for bacteria to target CEACAMs.
AU - van,Sorge NM
AU - Bonsor,DA
AU - Deng,L
AU - Lindahl,E
AU - Schmitt,V
AU - Lyndin,M
AU - Schmidt,A
AU - Nilsson,OR
AU - Brizuela,J
AU - Boero,E
AU - Sundberg,EJ
AU - van,Strijp JAG
AU - Doran,KS
AU - Singer,BB
AU - Lindahl,G
AU - McCarthy,AJ
DO - 10.15252/embj.2020106103
EP - 20
PY - 2021///
SN - 0261-4189
SP - 1
TI - Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors
T2 - The EMBO Journal
UR - http://dx.doi.org/10.15252/embj.2020106103
UR - https://www.ncbi.nlm.nih.gov/pubmed/33522633
UR - https://www.embopress.org/doi/full/10.15252/embj.2020106103
UR - http://hdl.handle.net/10044/1/86239
VL - 40
ER -
