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  • Journal article
    Brancaccio M, Enoki R, Mazuski CN, Jones J, Evans JA, Azzi Aet al., 2014,

    Network-Mediated Encoding of Circadian Time: The Suprachiasmatic Nucleus (SCN) from Genes to Neurons to Circuits, and Back

    , JOURNAL OF NEUROSCIENCE, Vol: 34, Pages: 15192-15199, ISSN: 0270-6474
  • Journal article
    Hastings MH, Brancaccio M, Maywood ES, 2014,

    Circadian pacemaking in cells and circuits of the suprachiasmatic nucleus

    , Journal of Neuroendocrinology, Vol: 26, Pages: 2-10, ISSN: 0953-8194

    The suprachiasmatic nucleus (SCN) of the hypothalamus is the principal circadian pacemaker of the brain. It co‐ordinates the daily rhythms of sleep and wakefulness, as well as physiology and behaviour, that set the tempo to our lives. Disturbance of this daily pattern, most acutely with jet‐lag but more insidiously with rotational shift‐work, can have severely deleterious effects for mental function and long‐term health. The present review considers recent developments in our understanding of the properties of the SCN that make it a robust circadian time‐keeper. It first focuses on the intracellular transcriptional/ translational feedback loops (TTFL) that constitute the cellular clockwork of the SCN neurone. Daily timing by these loops pivots around the negative regulation of the Period (Per) and Cryptochrome (Cry) genes by their protein products. The period of the circadian cycle is set by the relative stability of Per and Cry proteins, and this can be controlled by both genetic and pharmacological interventions. It then considers the function of these feedback loops in the context of cytosolic signalling by cAMP and intracellular calcium ([Ca2+]i), which are both outputs from, and inputs to, the TTFL, as well as the critical role of vasoactive intestinal peptide (VIP) signalling in synchronising cellular clocks across the SCN. Synchronisation by VIP in the SCN is paracrine, operating over an unconventionally long time frame (i.e. 24 h) and wide spatial domain, mediated via the cytosolic pathways upstream of the TTFL. Finally, we show how intersectional pharmacogenetics can be used to control G‐protein‐coupled signalling in individual SCN neurones, and how manipulation of Gq/[Ca2+]i‐signalling in VIP neurones can re‐programme the circuit‐level encoding of circadian time. Circadian pacemaking in the SCN therefore provides an unrivalled context in which to understand how a complex, adaptive behaviour can be organised by the dynamic activity of a relatively few gene
  • Journal article
    Maywood ES, Drynan L, Chesham JE, Edwards MD, Dardente H, Fustin J-M, Hazlerigg DG, O'Neill JS, Codner GF, Smyllie NJ, Brancaccio M, Hastings MHet al., 2013,

    Analysis of core circadian feedback loop in suprachiasmatic nucleus of <i>mCry1</i>-<i>luc</i> transgenic reporter mouse

    , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 9547-9552, ISSN: 0027-8424
  • Journal article
    Brancaccio M, Maywood ES, Chesham JE, Loudon ASI, Hastings MHet al., 2013,

    A Gq-Ca<SUP>2+</SUP> Axis Controls Circuit-Level Encoding of Circadian Time in the Suprachiasmatic Nucleus

    , NEURON, Vol: 78, Pages: 714-728, ISSN: 0896-6273
  • Journal article
    Brancaccio M, Pivetta C, Granzotto M, Filippis C, Mallamaci Aet al., 2010,

    <i>Emx2</i> and <i>Foxg1</i> Inhibit Gliogenesis and Promote Neuronogenesis

    , STEM CELLS, Vol: 28, Pages: 1206-1218, ISSN: 1066-5099

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For any enquiries about our lab, please contact:

Dr Marco Brancaccio
m.brancaccio@imperial.ac.uk

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