In this section
@article{Braddock:2022:10.1021/acs.orglett.1c04265,
author = {Braddock, D and Davies, J and Lickiss, P},
doi = {10.1021/acs.orglett.1c04265},
journal = {Organic Letters},
pages = {1175--1179},
title = {Methyltrimethoxysilane (MTM) as a reagent for direct amidation of carboxylic acids},
url = {http://dx.doi.org/10.1021/acs.orglett.1c04265},
volume = {24},
year = {2022}
}
TY - JOUR
AB - Methyltrimethoxysilane [MTM, CH3Si(OMe)3] has been demonstrated to be an effective, inexpensive, and safe reagent for the direct amidation of carboxylic acids with amines. Two simple workup procedures that provide the pure amide product without the need for further purification have been developed. The first employs an aqueous base-mediated annihilation of MTM. The second involves simple product crystallization from the reaction mixture providing a low process mass intensity direct amidation protocol.
AU - Braddock,D
AU - Davies,J
AU - Lickiss,P
DO - 10.1021/acs.orglett.1c04265
EP - 1179
PY - 2022///
SN - 1523-7052
SP - 1175
TI - Methyltrimethoxysilane (MTM) as a reagent for direct amidation of carboxylic acids
T2 - Organic Letters
UR - http://dx.doi.org/10.1021/acs.orglett.1c04265
UR - http://hdl.handle.net/10044/1/94935
VL - 24
ER -