BibTex format
@article{Campos-Pires:2020:10.1186/s13054-020-03373-9,
author = {Campos-Pires, R and Onggradito, H and Ujvari, E and Karimi, S and Valeo, F and Aldhoun, J and Edge, C and Franks, N and Dickinson, R},
doi = {10.1186/s13054-020-03373-9},
journal = {Critical Care (UK)},
pages = {1--18},
title = {Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study},
url = {http://dx.doi.org/10.1186/s13054-020-03373-9},
volume = {24},
year = {2020}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundTraumatic brain injury (TBI) is a major cause of morbidity and mortality, but there are no clinically proven treatments that specifically target neuronal loss and secondary injury development following TBI. In this study, we evaluate the effect of xenon treatment on functional outcome, lesion volume, neuronal loss and neuroinflammation after severe TBI in rats.MethodsYoung adult male Sprague Dawley rats were subjected to controlled cortical impact (CCI) brain trauma or sham surgery followed by treatment with either 50% xenon:25% oxygen balance nitrogen, or control gas 75% nitrogen:25% oxygen. Locomotor function was assessed using Catwalk-XT automated gait analysis at baseline and 24 h after injury. Histological outcomes were assessed following perfusion fixation at 15 min or 24 h after injury or sham procedure.ResultsXenon treatment reduced lesion volume, reduced early locomotor deficits, and attenuated neuronal loss in clinically relevant cortical and subcortical areas. Xenon treatment resulted in significant increases in Iba1-positive microglia and GFAP-positive reactive astrocytes that was associated with neuronal preservation.ConclusionsOur findings demonstrate that xenon improves functional outcome and reduces neuronal loss after brain trauma in rats. Neuronal preservation was associated with a xenon-induced enhancement of microglial cell numbers and astrocyte activation, consistent with a role for early beneficial neuroinflammation in xenon’s neuroprotective effect. These findings suggest that xenon may be a first-line clinical treatment for brain trauma.
AU - Campos-Pires,R
AU - Onggradito,H
AU - Ujvari,E
AU - Karimi,S
AU - Valeo,F
AU - Aldhoun,J
AU - Edge,C
AU - Franks,N
AU - Dickinson,R
DO - 10.1186/s13054-020-03373-9
EP - 18
PY - 2020///
SN - 1364-8535
SP - 1
TI - Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study
T2 - Critical Care (UK)
UR - http://dx.doi.org/10.1186/s13054-020-03373-9
UR - https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03373-9
UR - http://hdl.handle.net/10044/1/84925
VL - 24
ER -