Citation

BibTex format

@article{Boughton:2019:10.1038/s41598-019-43686-6,
author = {Boughton, O and Ma, S and Cai, X and Yan, L and Peralta, L and Laugier, P and Marrow, J and Giuliani, F and Hansen, U and Abel, R and Grimal, Q and Cobb, J},
doi = {10.1038/s41598-019-43686-6},
journal = {Scientific Reports},
title = {Computed tomography porosity and spherical indentation for determining cortical bone millimetre-scale mechanical properties},
url = {http://dx.doi.org/10.1038/s41598-019-43686-6},
volume = {9},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The cortex of the femoral neck is a key structural element of the human body, yet there is not a reliable metric for predicting the mechanical properties of the bone in this critical region. This study explored the use of a range of non-destructive metrics to measure femoral neck cortical bone stiffness at the millimetre length scale. A range of testing methods and imaging techniques were assessed for their ability to measure or predict the mechanical properties of cortical bone samples obtained from the femoral neck of hip replacement patients. Techniques that can potentially be applied in vivo to measure bone stiffness, including computed tomography (CT), bulk wave ultrasound (BWUS) and indentation, were compared against in vitro techniques, including compression testing, density measurements and resonant ultrasound spectroscopy. Porosity, as measured by micro-CT, correlated with femoral neck cortical bone’s elastic modulus and ultimate compressive strength at the millimetre length scale. Large-tip spherical indentation also correlated with bone mechanical properties at this length scale but to a lesser extent. As the elastic mechanical properties of cortical bone correlated with porosity, we would recommend further development of technologies that can safely measure cortical porosity in vivo.Introduction
AU  - Boughton,O
AU  - Ma,S
AU  - Cai,X
AU  - Yan,L
AU  - Peralta,L
AU  - Laugier,P
AU  - Marrow,J
AU  - Giuliani,F
AU  - Hansen,U
AU  - Abel,R
AU  - Grimal,Q
AU  - Cobb,J
DO  - 10.1038/s41598-019-43686-6
PY  - 2019///
SN  - 2045-2322
TI  - Computed tomography porosity and spherical indentation for determining cortical bone millimetre-scale mechanical properties
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-019-43686-6
UR  - http://hdl.handle.net/10044/1/70276
VL  - 9
ER  -
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